We’ve officially entered November, and with the first College Football Playoff rankings set to release next Tuesday night, Week 10 of the 2025 season greets us with the energy of a student realizing the final exam is tomorrow. The schedule offers no mercy and very little predictability, because significant matchups are back on the horizon and everyone’s margin for error has vanished. The weekend kicks off with ninth-ranked Vanderbilt testing its newfound legitimacy in Austin against 20th-ranked Texas, while top-ranked Ohio State braces for a Penn State team that’s bad enough to be dangerous. Down south, Georgia and Florida renew their annual cocktail of chaos in Jacksonville, and unbeaten Navy heads to North Texas in a matchup that features unlikely CFP implications. Meanwhile, Miami, Texas Tech, and Virginia all face tricky road tests that could undo months of goodwill in a single afternoon. Upset watches flash across the map, playoff hopes dangle by threads, and November’s first Saturday promises the kind of madness that only college football can choreograph, so let’s get into the matchups:

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Saturday, November 1

#9 Vanderbilt @ #20 Texas (-3.5) (O/U: 46.5)

DKR-Texas Memorial Stadium, Austin, TX

Noon, ABC

Best Bet: Quintrevion Wisner Anytime TD

Prediction

Final Score: #20 Texas 24, #9 Vanderbilt 17

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Penn State @ #1 Ohio State (-18.5) (O/U: 44.5)

Ohio Stadium, Columbus, OH

Noon, FOX

Best Bet: Under 44.5

Prediction

Final Score: #1 Ohio State 31, Penn State 7

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#10 Miami (-10.5) @ SMU (O/U: 50.5)

Gerald J. Ford Stadium, Dallas, TX

Noon, ESPN

Best Bet: Carson Beck o256.5 Passing Yards

Prediction

Final Score: #10 Miami 31, SMU 28

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Navy @ North Texas (-6.5) (O/U: 66.5)

DATCU Stadium, Denton, TX

Noon, ESPN2

Best Bet: Over 66.5

Prediction

Final Score: North Texas 38, Navy 35

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#5 Georgia (-7.5) vs. Florida (O/U: 50.5)

EverBank Stadium, Jacksonville, FL

3:30 pm, ABC

Best Bet: J. Michael Sturdivant o35.5 Receiving Yards

Prediction

Final Score: #7 Georgia 30, Florida 20

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#13 Texas Tech (-7.5) @ Kansas State (O/U: 51.5)

Bill Snyder Family Stadium, Manhattan, KS

3:30 pm, FOX

Best Bet: Avery Johnson o30.5 Rushing Yards

Prediction

Final Score: #13 Texas Tech 31, Kansas State 20

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#15 Virginia (-5.5) @ California (O/U: 53.5)

California Memorial Stadium, Berkeley, CA

3:45 pm, ESPN2

Best Bet: Trond Grizzell o41.5 Receiving Yards

Prediction

Final Score: California 30, #15 Virginia 23

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#18 Oklahoma @ #14 Tennessee (-2.5) (O/U: 55.5)

Neyland Stadium, Knoxville, TN

7:30 pm, ABC

Best Bet: Tennessee -2.5

Prediction

Final Score: #14 Tennessee 34, #18 Oklahoma 27

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#23 USC (-4.5) @ Nebraska (O/U: 59.5)

Memorial Stadium, Lincoln, NE

7:30 pm, NBC

Best Bet: Nebraska ML

Prediction

Final Score: Nebraska 27, #23 USC 24

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#17 Cincinnati @ #24 Utah (-11.5) (O/U: 56.5)

Rice-Eccles Stadium, Salt Lake City, UT

10:15 pm, ESPN

Best Bet: Cincinnati +11.5

Prediction

Final Score: #17 Cincinnati 31, #24 Utah 27

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Stay tuned this weekend for another stacked college football slate!