We’re just a couple of weeks away from Christmas and a few weeks away from the final games of the regular season, but Week 15 could potentially set the tone for the playoff picture as a collective whole. The week opens in Tampa Bay, where the Buccaneers host the Falcons in a pivotal NFC South clash, as Baker Mayfield looks to steady his offense and keep the division firmly within reach while Atlanta plays the role of spoiler behind Bijan Robinson. Sunday’s spotlight shifts to Foxborough for a high-stakes rematch between the Bills and Patriots, with Drake Maye and New England eyeing their first division crown since the post-Brady transition and Buffalo fighting to preserve its grip atop the AFC East. The late afternoon window delivers fireworks, led by a star-packed showdown in Los Angeles between the Lions and Rams, along with a rare interconference heavyweight bout in Denver as the Packers test the league-leading Broncos at altitude. Adding another layer of intrigue, Philip Rivers’ surprise return with the Colts sends Indianapolis into Seattle to face one of football’s most suffocating defenses. Sunday night shifts to Dallas for a must-win showdown between the Vikings and Cowboys, while Week 15 closes Monday in Pittsburgh, where Aaron Rodgers and the Steelers host a Dolphins team searching for late-season momentum. With postseason margins razor thin, here’s a closer look at what to expect from every matchup in Week 15:
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Thursday, December 11
Falcons @ Buccaneers (-5.5) (O/U: 43.5)
Raymond James Stadium, Tampa, FL
8:15 pm, Prime Video
Best Bet: Bucky Irving o14.5 Rush Attempts
Prediction
Final Score: Buccaneers 27, Falcons 16
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Sunday, December 14
Bills (-2.5) @ Patriots (O/U: 49.5)
Gillette Stadium, Foxborough, MA
1 pm, CBS
Best Bet: Patriots ML
Prediction
Final Score: Patriots 30, Bills 24
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Chargers @ Chiefs (-5.5) (O/U: 41.5)
GEHA Field at Arrowhead Stadium, Kansas City, MO
1 pm, CBS
Best Bet: Rashee Rice o71.5 Receiving Yards
Prediction
Final Score: Chiefs 24, Chargers 17
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Jets @ Jaguars (-13.5) (O/U: 41.5)
EverBank Stadium, Jacksonville, FL
1 pm, CBS
Best Bet: Travis Etienne Jr. Anytime TD
Prediction
Final Score: Jaguars 31, Jets 13
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Ravens (-2.5) @ Bengals (O/U: 51.5)
Paycor Stadium, Cincinnati, OH
1 pm, CBS
Best Bet: Over 51.5
Prediction
Final Score: Bengals 38, Ravens 34
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Browns @ Bears (-7.5) (O/U: 38.5)
Soldier Field, Chicago, IL
1 pm, FOX
Best Bet: Bears -7.5
Prediction
Final Score: Bears 26, Browns 13
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Raiders @ Eagles (-12.5) (O/U: 37.5)
Lincoln Financial Field, Philadelphia, PA
1 pm, FOX
Best Bet: DeVonta Smith o54.5 Receiving Yards
Prediction
Final Score: Eagles 27, Raiders 7
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Commanders @ Giants (-2.5) (O/U: 46.5)
MetLife Stadium, East Rutherford, NJ
1 pm, FOX
Best Bet: Tyrone Tracy Jr. o49.5 Rushing Yards
Prediction
Final Score: Giants 28, Commanders 24
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Cardinals @ Texans (-9.5) (O/U: 42.5)
NRG Stadium, Houston, TX
1 pm, FOX
Best Bet: Texans -9.5
Prediction
Final Score: Texans 24, Cardinals 7
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Colts @ Seahawks (-13.5) (O/U: 41.5)
Lumen Field, Seattle, WA
4:25 pm, CBS
Best Bet: Philip Rivers o0.5 Pass Interceptions
Prediction
Final Score: Seahawks 34, Colts 10
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Packers (-1.5) @ Broncos (O/U: 42.5)
Empower Field at Mile High, Denver, CO
4:25 pm, CBS
Best Bet: Under 42.5
Prediction
Final Score: Broncos 23, Packers 14
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Panthers (-2.5) @ Saints (O/U: 41.5)
Caesars Superdome, New Orleans, LA
4:25 pm, FOX
Best Bet: Panthers -2.5
Prediction
Final Score: Panthers 20, Saints 13
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Titans @ 49ers (-12.5) (O/U: 44.5)
Levi’s Stadium, Santa Clara, CA
4:25 pm, FOX
Best Bet: Brock Purdy o1.5 Passing TDs
Prediction
Final Score: 49ers 38, Titans 13
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Lions @ Rams (-5.5) (O/U: 54.5)
SoFi Stadium, Inglewood, CA
4:25 pm, FOX
Best Bet: Under 54.5
Prediction
Final Score: Rams 31, Lions 20
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Vikings @ Cowboys (-5.5) (O/U: 47.5)
AT&T Stadium, Arlington, TX
8:20 pm, NBC/Peacock
Best Bet: Cowboys -5.5
Prediction
Final Score: Cowboys 30, Vikings 13
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Monday, December 15
Dolphins @ Steelers (-2.5) (O/U: 42.5)
Acrisure Stadium, Pittsburgh, PA
8:15 pm, ABC/ESPN
Best Bet: Jaylen Warren o48.5 Rushing Yards
Prediction
Final Score: Steelers 23, Dolphins 16
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Make sure to stay tuned for another fantastic weekend of NFL football!

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