The calendar has finally delivered us to Thanksgiving weekend, and with many teams experiencing urgency to secure their postseason spots and climb their way back into divisional and Wild Card contention, the NFL is officially at its make-or-break point. Week 13 opens with the Lions’ traditional holiday showcase, offering Detroit a shot at redemption as the Packers roll into town after humiliating them during their Opening Weekend matchup. The spotlight then shifts south to Arlington, where the Cowboys ride the emotional high of a signature win over the defending Super Bowl champion Eagles into a heavyweight showdown with the visiting Chiefs, who appear to be slowly rediscovering their identity after edging the Colts last weekend. The holiday trilogy wraps up in Baltimore, where Joe Burrow’s long-awaited return from injury with the Bengals collides with a Ravens team surging into form at just the right moment. Sunday’s slate features its own stakes, as Daniel Jones and the Colts limp into a brutal defensive test against the Texans, while the Steelers become the stage for Josh Allen and Aaron Rodgers to chase rebounds and restore confidence. The prime-time window is reserved for contrasting realities, as the AFC’s elite, the Broncos and Patriots, look to extend their dominance against division-bottom Commanders and Giants squads desperate to salvage anything from injury-riddled campaigns. With postseason paths tightening and every possession magnified, Week 13 promises not just drama but clarity as the stretch run officially begins, so let’s dig a little deeper into what to expect out of each matchup:

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Thursday, November 27

Packers @ Lions (-2.5) (O/U: 47.5)

Ford Field, Detroit, MI

1 pm, FOX

Best Bet: Lions -2.5

Prediction

Final Score: Lions 28, Packers 24

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Chiefs (-3.5) @ Cowboys (O/U: 53.5)

AT&T Stadium, Arlington, TX

4:30 pm, CBS

Best Bet: CeeDee Lamb o6.5 Receptions

Prediction

Final Score: Chiefs 31, Cowboys 27

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Bengals @ Ravens (-7.5) (O/U: 52.5)

M&T Bank Stadium, Baltimore, MD

8:20 pm, NBC/Peacock

Best Bet: Ja’Marr Chase Anytime TD

Prediction

Final Score: Ravens 30, Bengals 16

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Friday, November 28

Bears @ Eagles (-6.5) (O/U: 43.5)

Lincoln Financial Field, Philadelphia, PA

3 pm, Prime Video

Best Bet: Eagles -6.5

Prediction

Final Score: Eagles 27, Bears 17

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Sunday, November 30

Rams (-9.5) @ Panthers (O/U: 44.5)

Bank of America Stadium, Charlotte, NC

1 pm, FOX

Best Bet: Over 44.5

Prediction

Final Score: Rams 34, Panthers 23

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Cardinals @ Buccaneers (-4.5) (O/U: 45.5)

Raymond James Stadium, Tampa, FL

1 pm, FOX

Best Bet: Trey McBride o68.5 Receiving Yards

Prediction

Final Score: Buccaneers 23, Cardinals 20

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Falcons (-2.5) @ Jets (O/U: 38.5)

MetLife Stadium, East Rutherford, NJ

1 pm, FOX

Best Bet: Under 38.5

Prediction

Final Score: Falcons 17, Jets 13

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Saints @ Dolphins (-5.5) (O/U: 41.5)

Hard Rock Stadium, Miami Gardens, FL

1 pm, FOX

Best Bet: DeVon Achane o79.5 Rushing Yards

Prediction

Final Score: Dolphins 20, Saints 13

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Texans @ Colts (-3.5) (O/U: 44.5)

Lucas Oil Stadium, Indianapolis, IN

1 pm, CBS

Best Bet: Texans +3.5

Prediction

Final Score: Texans 24, Colts 21

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49ers (-5.5) @ Browns (O/U: 35.5)

Huntington Bank Field, Cleveland, OH

1 pm, CBS

Best Bet: George Kittle o52.5 Receiving Yards

Prediction

Final Score: 49ers 24, Browns 16

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Jaguars (-5.5) @ Titans (O/U: 42.5)

Nissan Stadium, Nashville, TN

1 pm, CBS

Best Bet: Jaguars -5.5

Prediction

Final Score: Jaguars 27, Titans 6

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Vikings @ Seahawks (-12.5) (O/U: 41.5)

Lumen Field, Seattle, WA

4:05 pm, FOX

Best Bet: Seahawks -12.5

Prediction

Final Score: Seahawks 27, Vikings 3

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Raiders @ Chargers (-9.5) (O/U: 40.5)

SoFi Stadium, Inglewood, CA

4:25 pm, CBS

Best Bet: Justin Herbert o235.5 Passing Yards

Prediction

Final Score: Chargers 26, Raiders 17

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Bills (-3.5) @ Steelers (O/U: 44.5)

Acrisure Stadium, Pittsburgh, PA

4:25 pm, CBS

Best Bet: Steelers ML

Prediction

Final Score: Steelers 23, Bills 17

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Broncos (-6.5) @ Commanders (O/U: 43.5)

Northwest Stadium, Landover, MD

8:20 pm, NBC

Best Bet: RJ Harvey o75.5 Rushing + Receiving Yards

Prediction

Final Score: Broncos 27, Commanders 9

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Monday, December 1

Giants @ Patriots (-7.5) (O/U: 46.5)

Gillette Stadium, Foxborough, MA

8:15 pm, ABC/ESPN

Best Bet: Wan’Dale Robinson o5.5 Receptions

Prediction

Final Score: Patriots 31, Giants 14

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Make sure to keep an eye out for more picks as another big weekend of football progresses!