We’re now deep into November, and with Rivalry Week just one page away on the calendar, Week 13 arrives posing as a supposed “rest week” for many, although college football is always bound to give us excitement on a weekly basis. The slate may appear kinder than what November usually offers, yet it still delivers heavyweight moments like Missouri’s trip to Norman to face former Big XII rival Oklahoma for the second edition of their renewed rivalry since the Sooners’ move to the SEC in addition USC’s visit to Eugene to face Oregon in the weekend’s lone top-15 matchup featuring two former Pac-12 rivals now in the B1G. Both matchups seem determined to ensure that nobody drifts into rivalry week with their nerves intact, and teams are hoping for a breather instead find themselves navigating landmines disguised as standard Saturday contests, as every conference contributes its own version of a trapdoor game ready to flip a narrative or puncture a playoff dream. And though this weekend isn’t meant to overshadow the chaos waiting next week, it still manages to provide a full spread of meaningful, tension-filled football that will shape the final stretch. With that, it’s time to dive into the matchups that define the weekend ahead, so let’s get to it:

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Saturday, November 22

#22 Missouri @ #8 Oklahoma (-5.5) (O/U: 43.5)

Gaylord Family Oklahoma Memorial Stadium, Norman, OK

Noon, ABC

Best Bet: Xavier Robinson o53.5 Rushing Yards

Prediction

Final Score: #8 Oklahoma 24, #22 Missouri 17

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Louisville @ SMU (-4.5) (O/U: 50.5)

Gerald J. Ford Stadium, Dallas, TX

Noon, ESPN2

Best Bet: SMU -4.5

Prediction

Final Score: SMU 34, Louisville 17

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Washington State @ James Madison (-13.5) (O/U: 43.5)

Bridgeforth Stadium, Harrisonburg, VA

1 pm, ESPN+

Best Bet: Alonza Barnett III Anytime TD

Prediction

Final Score: James Madison 31, Washington State 14

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Montana State (-2.5) @ Montana (O/U: 59.5)

Washington-Grizzly Stadium, Missoula, MT

2 pm, ESPN+

Best Bet: Montana ML

Prediction

Final Score: Montana 28, Montana State 24

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#15 USC @ #7 Oregon (-10.5) (O/U: 59.5)

Autzen Stadium, Eugene, OR

3:30 pm, CBS

Best Bet: Ja’Kobi Lane o53.5 Receiving Yards

Prediction

Final Score: #7 Oregon 31, #15 USC 20

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TCU @ #23 Houston (-1.5) (O/U: 55.5)

TDECU Stadium, Houston, TX

4 pm, FOX

Best Bet: Connor Weigman o1.5 Passing TDs

Prediction

Final Score: TCU 30, #23 Houston 23

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Pittsburgh @ #16 Georgia Tech (-2.5) (O/U: 60.5)

Bobby Dodd Stadium, Atlanta, GA

7 pm, ESPN

Best Bet: Under 60.5

Prediction

Final Score: Pittsburgh 31, #16 Georgia Tech 27

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Nebraska @ Penn State (-7.5) (O/U: 45.5)

Beaver Stadium, University Park, PA

7 pm, NBC

Best Bet: Kaytron Allen o100.5 Rushing Yards

Prediction

Final Score: Penn State 23, Nebraska 20

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#20 Tennessee (-3.5) @ Florida (O/U: 57.5)

Ben Hill Griffin Stadium, Gainesville, FL

7:30 pm, ABC

Best Bet: Over 57.5

Prediction

Final Score: Florida 38, #20 Tennessee 34

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#11 BYU (-2.5) @ Cincinnati (O/U: 55.5)

Nippert Stadium, Cincinnati, OH

8 pm, FOX

Best Bet: BYU -2.5

Prediction

Final Score: #11 BYU 27, Cincinnati 23

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Make sure to stay on the lookout this weekend as we gear up for Rivalry Week!