With just three weeks left in the regular season, Week 12 arrives with every conference somehow holding a game that feels far too important for anyone’s comfort, as the sport’s annual November tension spreads itself evenly across the map. Clemson’s Friday night trip to top-20 Louisville offers the ACC its usual reminder of unpredictability, while Saturday turns into a nationwide buffet of significance, highlighted by Pittsburgh hosting College Gameday for the first time in years as Notre Dame faces yet another obstacle on its winding CFP path, and Michigan’s meeting with Northwestern adds the Big Ten’s weekly dose of upset anxiety. The Big XII refuses to be overshadowed, sending TCU to challenge BYU after the Cougars’ stunning stumble a week ago, just as the SEC doubles down on drama with Oklahoma’s visit to Alabama and Texas’ top-ten showdown at Georgia, proving November still hates subtlety. And with more ranked duels scattered coast to coast, the weekend once again reminds us that significance is a shared burden long before Selection Sunday arrives. With that, let’s dive into the weekend’s best matchups:

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Friday, November 14

Clemson @ #20 Louisville (-2.5) (O/U: 51.5)

L&N Federal Credit Union Stadium, Louisville, KY

7:30 pm, ESPN

Best Bet: Over 51.5

Prediction

Final Score: #20 Louisville 31, Clemson 24

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Saturday, November 15

#9 Notre Dame (-12.5) @ #22 Pittsburgh (O/U: 53.5)

Acrisure Stadium, Pittsburgh, PA

Noon, ABC

Best Bet: Notre Dame -12.5

Prediction

Final Score: #9 Notre Dame 38, #22 Pittsburgh 10

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#18 Michigan vs. Northwestern (O/U: 41.5)

Wrigley Field, Chicago, IL

Noon, FOX

Best Bet: Caleb Komolafe Anytime TD

Prediction

Final Score: #18 Michigan 23, Northwestern 13

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#24 USF (-9.5) @ Navy (O/U: 62.5)

Navy-Marine Corps Memorial Stadium, Annapolis, MD

Noon, ESPN2

Best Bet: Nykahi Davenport o54.5 Rushing Yards

Prediction

Final Score: #24 USF 41, Navy 34

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Arizona @ #25 Cincinnati (-6.5) (O/U: 56.5)

Nippert Stadium, Cincinnati, OH

Noon, FS1

Best Bet: Cincinnati -6.5

Prediction

Final Score: #25 Cincinnati 34, Arizona 23

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#11 Oklahoma @ #4 Alabama (-5.5) (O/U: 46.5)

Bryant-Denny Stadium, Tuscaloosa, AL

3:30 pm, ABC

Best Bet: John Mateer o206.5 Passing Yards

Prediction

Final Score: #4 Alabama 24, #11 Oklahoma 20

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#21 Iowa @ #17 USC (-7.5) (O/U: 49.5)

Los Angeles Memorial Coliseum, Los Angeles, CA

3:30 pm, B1G Network

Best Bet: Iowa +7.5

Prediction

Final Score: #17 USC 23, #21 Iowa 16

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#19 Virginia @ Duke (-5.5) (O/U: 59.5)

Wallace Wade Stadium, Durham, NC

3:30 pm, ESPN2

Best Bet: Over 59.5

Prediction

Final Score: Duke 35, #19 Virginia 31

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#10 Texas @ #5 Georgia (-6.5) (O/U: 50.5)

Sanford Stadium, Athens, GA

7:30 pm, ABC

Best Bet: DeAndre Moore Jr. Longest Reception o17.5 Yards

Prediction

Final Score: #5 Georgia 27, #10 Texas 17

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TCU @ #12 BYU (-4.5) (O/U: 50.5)

LaVell Edwards Stadium, Provo, UT

10:15 pm, ESPN

Best Bet: Eric McAlister o82.5 Receiving Yards

Prediction

Final Score: #12 BYU 30, TCU 20

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Stay tuned this weekend for yet another stacked weekend of college football!