With the trade deadline officially behind us, the NFL shifts full focus toward the playoff chase as Week 10 delivers a new round of high-stakes matchups across the league. The week opens Thursday night in Denver, where the red-hot Broncos, now tied with the Colts and Patriots atop the AFC standings, look to keep their momentum rolling against a Raiders team desperate to stay relevant in the division race. Overseas, the Falcons and Colts will make history in Berlin, marking the NFL’s first-ever game in the German capital and the fourth overall played in the country. Sunday’s slate features a headline-grabbing “Tom Brady Bowl” between the Patriots and Buccaneers, as both teams enter near the top of their divisions with a chance to grab full control of their conference standings. Elsewhere in the NFC West, the Seahawks host the Cardinals following strong wins from both sides, while the 49ers and Rams renew their rivalry in another divisional showdown. Sunday night offers a marquee quarterback duel in Los Angeles between Aaron Rodgers’ Steelers and Justin Herbert’s Chargers, before a Monday night showdown between the Eagles and Packers caps off the week in style. With contenders separating from pretenders, Week 10 sets the tone for what’s sure to be a thrilling second-half run, so let’s dive into these matchups that are sure to live up to expectations:

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Thursday, November 6

Raiders @ Broncos (-9.5) (O/U: 42.5)

Empower Field at Mile High, Denver, CO

8:15 pm, Prime Video

Best Bet: Broncos -9.5

Prediction

Final Score: Broncos 31, Raiders 10

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Sunday, November 9

Falcons vs. Colts (-6.5) (O/U: 47.5)

Olympiastadion Berlin, Berlin, Germany

9:30 am, NFL Network

Best Bet: Jonathan Taylor o92.5 Rushing Yards

Prediction

Final Score: Colts 28, Falcons 24

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Patriots @ Buccaneers (-2.5) (O/U: 48.5)

Raymond James Stadium, Tampa, FL

1 pm, CBS

Best Bet: Drake Maye o1.5 Passing TDs

Prediction

Final Score: Buccaneers 27, Patriots 20

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Jaguars (-1.5) @ Texans (O/U: 37.5)

NRG Stadium, Houston, TX

1 pm, CBS

Best Bet: Jaguars -1.5

Prediction

Final Score: Jaguars 20, Texans 16

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Browns (-2.5) @ Jets (O/U: 37.5)

MetLife Stadium, East Rutherford, NJ

1 pm, CBS

Best Bet: Quinshon Judkins o19.5 Rushing Attempts

Prediction

Final Score: Browns 16, Jets 9

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Bills (-8.5) @ Dolphins (O/U: 49.5)

Hard Rock Stadium, Miami Gardens, FL

1 pm, CBS

Best Bet: Bills -8.5

Prediction

Final Score: Bills 31, Dolphins 14

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Ravens (-4.5) @ Vikings (O/U: 49.5)

U.S. Bank Stadium, Minneapolis, MN

1 pm, FOX

Best Bet: Justin Jefferson o72.5 Receiving Yards

Prediction

Final Score: Ravens 24, Vikings 16

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Saints @ Panthers (-5.5) (O/U: 38.5)

Bank of America Stadium, Charlotte, NC

1 pm, FOX

Best Bet: Over 38.5

Prediction

Final Score: Panthers 27, Saints 13

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Giants @ Bears (-4.5) (O/U: 47.5)

Soldier Field, Chicago, IL

1 pm, FOX

Best Bet: Caleb Williams o230.5 Passing Yards

Prediction

Final Score: Bears 34, Giants 23

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Cardinals @ Seahawks (-6.5) (O/U: 45.5)

Lumen Field, Seattle, WA

4:05 pm, CBS

Best Bet: Under 45.5

Prediction

Final Score: Seahawks 24, Cardinals 13

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Lions (-7.5) @ Commanders (O/U: 49.5)

Northwest Stadium, Landover, MD

4:25 pm, FOX

Best Bet: Zach Ertz o3.5 Receptions

Prediction

Final Score: Lions 30, Commanders 13

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Rams (-4.5) @ 49ers (O/U: 49.5)

Levi’s Stadium, Santa Clara, CA

4:25 pm, FOX

Best Bet: 49ers ML

Prediction

Final Score: 49ers 27, Rams 23

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Steelers @ Chargers (-2.5) (O/U: 45.5)

SoFi Stadium, Inglewood, CA

8:20 pm, NBC/Peacock

Best Bet: Over 45.5

Prediction

Final Score: Steelers 27, Chargers 24

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Monday, November 10

Eagles @ Packers (-1.5) (O/U: 45.5)

Lambeau Field, Green Bay, WI

8:15 pm, ABC/ESPN

Best Bet: Jalen Hurts Anytime TD

Prediction

Final Score: Eagles 23, Packers 17

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Make sure to keep an eye out for more picks as another big weekend of football progresses!