The NFL season is beginning to take real shape, and we have yet another slate loaded with defining matchups, intriguing betting lines, and storylines that could reshape the standings heading into mid-October. Some teams are beginning to find rhythm and consistency, while others are searching for answers as the pressure of staying in the playoff hunt starts to build. The action opens Thursday night in East Rutherford, where the Eagles head to the Meadowlands to face the rival Giants in a primetime showdown with Jaxson Dart looking to bounce back after last week’s tough loss in New Orleans. Sunday morning takes the league back to London for the Broncos and Jets, and across the afternoon slate, the Rams travel to Baltimore for a heavyweight clash, the Seahawks and Jaguars meet in one of the weekend’s most evenly matched contests, and the Cowboys head to Charlotte hoping to slow down a Panthers offense that’s quietly heating up. The schedule crescendos Sunday night when the Lions visit the Chiefs in a blockbuster showdown that could help Kansas City get back on the right path, before closing with a Monday night doubleheader featuring the Bills-Falcons and Bears-Commanders. With the playoff picture slowly starting to form and oddsmakers tightening their margins, here’s a full look at the Week 6 rundown:

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Thursday, October 9

Eagles (-7.5) @ Giants (O/U: 40.5)

MetLife Stadium, East Rutherford, NJ

8:15 pm, Prime Video

Best Bet: Saquon Barkley Anytime TD

Prediction

Final Score: Eagles 27, Giants 10

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Sunday, October 12

Broncos (-6.5) vs. Jets (O/U: 43.5)

Tottenham Hotspur Stadium, London, UK

9:30 am, NFL Network

Best Bet: Under 43.5

Prediction

Final Score: Broncos 27, Jets 10

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Rams (-6.5) @ Ravens (O/U: 43.5)

M&T Bank Stadium, Baltimore, MD

1 pm, FOX

Best Bet: Rams -6.5

Prediction

Final Score: Rams 34, Ravens 13

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Seahawks (-1.5) @ Jaguars (O/U: 46.5)

EverBank Stadium, Jacksonville, FL

1 pm, FOX

Best Bet: Brian Thomas Jr. o60.5 Receiving Yards

Prediction

Final Score: Seahawks 27, Jaguars 23

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Cowboys (-2.5) @ Panthers (O/U: 47.5)

Bank of America Stadium, Charlotte, NC

1 pm, FOX

Best Bet: Over 47.5

Prediction

Final Score: Panthers 30, Cowboys 24

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Cardinals @ Colts (-8.5) (O/U: 46.5)

Lucas Oil Stadium, Indianapolis, IN

1 pm, FOX

Best Bet: Jonathan Taylor o88.5 Rushing Yards

Prediction

Final Score: Colts 31, Cardinals 7

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Browns @ Steelers (-6.5) (O/U: 38.5)

Acrisure Stadium, Pittsburgh, PA

1 pm, CBS

Best Bet: Under 38.5

Prediction

Final Score: Steelers 20, Browns 13

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Chargers (-3.5) @ Dolphins (O/U: 44.5)

Hard Rock Stadium, Miami Gardens, FL

1 pm, CBS

Best Bet: Keenan Allen o5.5 Receptions

Prediction

Final Score: Chargers 27, Dolphins 17

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Patriots (-3.5) @ Saints (O/U: 45.5)

Caesars Superdome, New Orleans, LA

1 pm, CBS

Best Bet: Patriots -3.5

Prediction

Final Score: Patriots 24, Saints 13

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Titans @ Raiders (-3.5) (O/U: 41.5)

Allegiant Stadium, Las Vegas, NV

4:05 pm, FOX

Best Bet: Cam Ward o31.5 Pass Attempts

Prediction

Final Score: Raiders 23, Titans 17

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Bengals @ Packers (-13.5) (O/U: 44.5)

Lambeau Field, Green Bay, WI

4:25 pm, CBS

Best Bet: Micah Parsons o0.5 Sacks

Prediction

Final Score: Packers 34, Bengals 17

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49ers @ Buccaneers (-3.5) (O/U: 46.5)

Raymond James Stadium, Tampa, FL

4:25 pm, CBS

Best Bet: Over 46.5

Prediction

Final Score: Buccaneers 31, 49ers 24

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Lions @ Chiefs (-2.5) (O/U: 51.5)

GEHA Field at Arrowhead Stadium, Kansas City, MO

8:20 pm, NBC/Peacock

Best Bet: Lions ML

Prediction

Final Score: Lions 28, Chiefs 23

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Monday, October 13

Bills (-3.5) @ Falcons (O/U: 49.5)

Mercedes-Benz Stadium, Atlanta, GA

7:15 pm, ESPN

Best Bet: Falcons +3.5

Prediction

Final Score: Falcons 35, Bills 31

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Bears @ Commanders (-5.5) (O/U: 48.5)

Northwest Stadium, Landover, MD

8:15 pm, ABC/ESPN

Best Bet: Caleb Williams o230.5 Passing Yards

Prediction

Final Score: Commanders 30, Bears 27

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Make sure to keep an eye out for more picks as another big weekend of football progresses!