After a weekend of even more chaos, carnage, and upsets, Week 6 of the 2025 college football season feels like it’s finally downshifting, or at least trying to convince us that it is, because while the national slate lacks the obvious blockbusters that defined September, it still refuses to be entirely dismissed. The weekend doesn’t belong to any single conference, instead spreading its drama evenly across the Power Four, which feels like college football’s way of saying, “fine, everyone can suffer a little.” In the ACC, red-hot Miami’s in-state trip up north to a Florida State team coming off of a loss renews one of the sport’s most volatile rivalries, where every inch of field position doubles as a referendum on pride and patience. The SEC offers its own brand of chaos as the surging Commodores of Vanderbilt attempts to shock top-ten Alabama for the second straight year, a thought that still feels impossible and yet strangely plausible. Meanwhile, 11th-ranked Texas Tech and unranked Houston turn the Big XII into a battle for Texas supremacy between two unbeaten programs nobody expected to be here, and Boise State’s journey to face #21 Notre Dame in South Bend doubles as both a redemption story and a warning shot opportunity from the Group of Five. It may not look like a seismic Saturday on paper, but that’s often when college football turns sneaky, so let’s look into this upcoming weekend that has all the quiet tension of a storm waiting to break:

—————————————————————————————————————————————

Saturday, October 4

#14 Iowa State @ Cincinnati (-1.5) (O/U: 55.5)

Nippert Stadium, Cincinnati, OH

Noon, ESPN2

Best Bet: Brendan Sorsby Anytime TD

Prediction

Final Score: Cincinnati 28, #14 Iowa State 24

—————————————————————————————————————————————

#9 Texas (-4.5) @ Florida (O/U: 42.5)

Ben Hill Griffin Stadium, Gainesville, FL

3:30 pm, ESPN

Best Bet: Vernell Brown o41.5 Receiving Yards

Prediction

Final Score: Florida 21, #9 Texas 17

—————————————————————————————————————————————

Boise State @ #21 Notre Dame (-20.5) (O/U: 63.5)

Notre Dame Stadium, South Bend, IN

3:30 pm, NBC/Peacock

Best Bet: Notre Dame Team Total o41.5

Prediction

Final Score: #21 Notre Dame 52, Boise State 14

—————————————————————————————————————————————

#16 Vanderbilt @ #10 Alabama (-11.5) (O/U: 55.5)

Bryant-Denny Stadium, Tuscaloosa, AL

3:30 pm, ABC

Best Bet: Vanderbilt +11.5

Prediction

Final Score: #10 Alabama 27, #16 Vanderbilt 20

—————————————————————————————————————————————

#24 Virginia @ Louisville (-6.5) (O/U: 61.5)

L&N Federal Credit Union Stadium, Louisville, KY

3:30 pm, ESPN2

Best Bet: Isaac Brown o69.5 Rushing Yards

Prediction

Final Score: Louisville 38, #24 Virginia 35

—————————————————————————————————————————————

Washington (-6.5) @ Maryland (O/U: 53.5)

SECU Stadium, College Park, MD

3:30 pm, B1G Network

Best Bet: Malik Washington o240.5 Passing Yards

Prediction

Final Score: Washington 30, Maryland 23

—————————————————————————————————————————————

#11 Texas Tech (-11.5) @ Houston (O/U: 52.5)

TDECU Stadium, Houston, TX

7 pm, ESPN

Best Bet: Under 52.5

Prediction

Final Score: #11 Texas Tech 31, Houston 13

—————————————————————————————————————————————

Mississippi State @ #6 Texas A&M (-16.5) (O/U: 55.5)

Kyle Field, College Station, TX

7:30 pm, SEC Network

Best Bet: Mario Craver Anytime TD

Prediction

Final Score: #6 Texas A&M 34, Mississippi State 24

—————————————————————————————————————————————

#3 Miami (-4.5) @ #18 Florida State (O/U: 54.5)

Doak Campbell Stadium, Tallahassee, FL

7:30 pm, ABC

Best Bet: Florida State ML

Prediction

Final Score: #18 Florida State 27, #3 Miami 24

—————————————————————————————————————————————

Duke (-2.5) @ California (O/U: 55.5)

California Memorial Stadium, Berkeley, CA

10:30 pm, ESPN

Best Bet: Duke -2.5

Prediction

Final Score: Duke 31, California 20

—————————————————————————————————————————————

Make sure to stay tuned this weekend for one of the more stacked and exciting weekends of the college football season!