We’re finally hitting the end of September, and with it comes a schedule that blends divisional tension, international flair, and heavyweight showdowns as we prepare to begin the Week 4 slate. The slate opens Thursday night in Glendale, where the Seahawks and Cardinals meet in a matchup that could prove critical to shape the NFC West pecking order, and it carries through Sunday morning when the Vikings and Steelers take their rivalry overseas to Dublin in a showcase game for fans abroad for the second international game this season and the first since the Chiefs and Chargers met in São Paulo. From there, the action only ramps up, as the Eagles’ trip to Tampa Bay puts Jalen Hurts and Saquon Barkley against a Buccaneers run defense that has been among the league’s most disruptive through three weeks, while Lamar Jackson and the Ravens march into Kansas City for another clash with Patrick Mahomes that could still have implications for the top of the AFC even though both teams currently sit at 1-2. Add in the Micah Parsons homecoming in Dallas and a Monday night doubleheader that includes an AFC doubleheader, and this weekend delivers the kind of storylines that could set the tone for the season’s next stretch, so once again, let’s take a quick deep dive into each clash:

—————————————————————————————————————————————

Thursday, September 25

Seahawks (-1.5) @ Cardinals (O/U: 43.5)

State Farm Stadium, Glendale, AZ

8:15 pm, Prime Video

Best Bet: Seahawks -1.5

Prediction

Final Score: Seahawks 24, Cardinals 17

—————————————————————————————————————————————

Sunday, September 28

Vikings (-2.5) vs. Steelers (O/U: 41.5)

Croke Park, Dublin, Ireland

9:30 am, NFL Network

Best Bet: Jalen Nailor o16.5 Receiving Yards

Prediction

Final Score: Vikings 20, Steelers 17

—————————————————————————————————————————————

Eagles (-3.5) @ Buccaneers (O/U: 43.5)

Raymond James Stadium, Tampa, FL

1 pm, FOX

Best Bet: Buccaneers ML

Prediction

Final Score: Buccaneers 27, Eagles 23

—————————————————————————————————————————————

Panthers @ Patriots (-5.5) (O/U: 42.5)

Gillette Stadium, Foxborough, MA

1 pm, FOX

Best Bet: Tre’Veyon Henderson o18.5 Receiving Yards

Prediction

Final Score: Patriots 23, Panthers 20

—————————————————————————————————————————————

Browns @ Lions (-9.5) (O/U: 44.5)

Ford Field, Detroit, MI

1 pm, FOX

Best Bet: Amon-Ra St. Brown o5.5 Receptions

Prediction

Final Score: Lions 28, Browns 13

—————————————————————————————————————————————

Commanders @ Falcons (-2.5) (O/U: 43.5)

Mercedes-Benz Stadium, Atlanta, GA

1 pm, CBS

Best Bet: Over 43.5

Prediction

Final Score: Commanders 31, Falcons 28

—————————————————————————————————————————————

Chargers (-6.5) @ Giants (O/U: 42.5)

MetLife Stadium, East Rutherford, NJ

1 pm, CBS

Best Bet: Chargers -6.5

Prediction

Final Score: Chargers 31, Giants 17

—————————————————————————————————————————————

Titans @ Texans (-7.5) (O/U: 39.5)

NRG Stadium, Houston, TX

1 pm, CBS

Best Bet: Nico Collins Anytime TD

Prediction

Final Score: Texans 20, Titans 13

—————————————————————————————————————————————

Saints @ Bills (-15.5) (O/U: 48.5)

Highmark Stadium, Orchard Park, NY

1 pm, CBS

Best Bet: Over 48.5

Prediction

Final Score: Bills 38, Saints 13

—————————————————————————————————————————————

Colts @ Rams (-3.5) (O/U: 49.5)

SoFi Stadium, Inglewood, CA

4:05 pm, FOX

Best Bet: Blake Corum o22.5 Rushing Yards

Prediction

Final Score: Rams 34, Colts 30

—————————————————————————————————————————————

Jaguars @ 49ers (-3.5) (O/U: 45.5)

Levi’s Stadium, Santa Clara, CA

4:05 pm, FOX

Best Bet: Under 45.5

Prediction

Final Score: 49ers 23, Jaguars 16

—————————————————————————————————————————————

Bears @ Raiders (-1.5) (O/U: 47.5)

Allegiant Stadium, Las Vegas, NV

4:25 pm, CBS

Best Bet: Caleb Williams o1.5 Passing TDs

Prediction

Final Score: Bears 31, Raiders 20

—————————————————————————————————————————————

Ravens (-2.5) @ Chiefs (O/U: 49.5)

GEHA Field at Arrowhead Stadium, Kansas City, MO

4:25 pm, CBS

Best Bet: Ravens -2.5

Prediction

Final Score: Ravens 27, Chiefs 20

—————————————————————————————————————————————

Packers (-6.5) @ Cowboys (O/U: 46.5)

AT&T Stadium, Arlington, TX

8:20 pm, NBC/Peacock

Best Bet: Micah Parsons o0.5 Sacks

Prediction

Final Score: Packers 27, Cowboys 10

—————————————————————————————————————————————

Monday, September 29

Jets @ Dolphins (-2.5) (O/U: 44.5)

Hard Rock Stadium, Miami Gardens, FL

7:15 pm, ESPN

Best Bet: Garrett Wilson o65.5 Receiving Yards

Prediction

Final Score: Jets 24, Dolphins 20

—————————————————————————————————————————————

Bengals @ Broncos (-7.5) (O/U: 44.5)

Empower Field at Mile High, Denver, CO

8:15 pm, ABC/ESPN

Best Bet: Broncos -7.5

Prediction

Final Score: Broncos 31, Bengals 14

—————————————————————————————————————————————

Make sure to stay tuned this weekend as we sit back and enjoy a stacked Week 4 slate to add onto a fantastic weekend of sports altogether!