The third week of the 2025 NFL season won’t quite match the blockbuster storytelling of last weekend, yet it still delivers a slate fairly heavy on divisional battles again. Rivalries will once again test early-season resilience, though the narratives this time lean less on championship echoes and more on coaching reunions that carry their own intrigue. The AFC West becomes the stage for one of the week’s headliners, as Sean Payton’s Broncos travel to Los Angeles for a chess match against Jim Harbaugh’s Chargers, a duel between two former NFC coaches now shaping new identities out west. Todd Bowles also finds himself at the center of attention, with his Buccaneers hosting the Jets, who had previously fired Bowles in 2018, and his group looks more set than ever to help their coach get back at his former team. And while those storylines set the table, the most exciting of them all may come under the primetime spotlight, where the Lions and Ravens, two of the league’s most explosive offenses, square off in a Monday night showcase that could double as an early playoff preview. With divisional skirmishes adding fuel across the schedule and several high-profile reunions anchoring the drama, This week offers fewer headlines than its predecessor but remains rich with angles that will shape the season’s early rhythm, so with that in mind, let’s very briefly take look at the matchups:

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Thursday, September 18

Dolphins @ Bills (-11.5) (O/U: 50.5)

Highmark Stadium, Orchard Park, NY

8:15 pm, Prime Video

We begin this weekend’s slate with two AFC East squads trending in different directions, as Buffalo hosts Miami under the lights on Thursday night, and the atmosphere in Orchard Park should be electric with Josh Allen leading a roster that blends elite talent and disciplined coaching. The Bills have rediscovered their defensive edge with Ed Oliver anchoring the front and Joey Bosa bringing disruption off the edge, and even without Matt Milano, they are built to force long-yardage situations that create turnovers. Miami, meanwhile, enters with lingering flaws in pass protection and situational execution, as Tua Tagovailoa’s timing can still spring Tyreek Hill and Jaylen Waddle free, yet too many drives stall under pressure, leaving their rebuilt defense to cover mistakes that Buffalo is poised to exploit.

Best Bet: Over 50.5

This rivalry has consistently delivered points, with nine of the last 14 meetings going over this total, and the conditions are in place for another high-scoring night. Miami’s inconsistency doesn’t erase its explosiveness, as Hill, Waddle, and Achane can reach the scoreboard quickly without needing long drives, while Buffalo’s offense has already shown it can overwhelm disciplined defenses with Allen’s improvisation and weapons like Khalil Shakir and Dalton Kincaid. Even when the Bills slow the tempo with James Cook’s physical running, they eventually open space for deep strikes, so given Buffalo’s firepower and Miami’s big-play ability, the over feels like the strongest angle.

Prediction

This game should remain competitive into the second half, as Miami’s speed ensures they will land a few explosive shots, but Buffalo’s balance and depth ultimately make the difference. McDermott’s defense thrives on disguised pressures and momentum swings that rattle Tagovailoa, while the offense can dictate tempo with Cook’s running and Allen’s mobility creating space for Shakir, Keon Coleman, and Kincaid. Even if Miami hangs around early, Buffalo’s discipline and versatility should tilt the field late, and I expect a sustained fourth-quarter touchdown drive to secure the outcome and push the Bills to 3-0 while Miami falls to 0-3.

Final Score: Bills 34, Dolphins 20

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Sunday, September 21

Bengals @ Vikings (-2.5) (O/U: 41.5)

U.S. Bank Stadium, Minneapolis, MN

1 pm, CBS

This feels like one of those early-season matchups where both teams have something to prove, and the storylines are thick with intrigue. Cincinnati turns to Jake Browning in place of the injured Joe Burrow, and the Bengals know they’ll need to establish rhythm on the ground to ease the pressure on their backup quarterback. The Vikings, also without J.J. McCarthy, counter with a defense anchored by Brian Flores’ relentless pressure looks, but Minnesota has been leaky against the run, opening the door for the Bengals’ backfield to play a larger role than usual. With the noise inside U.S. Bank Stadium likely to make life tough for Browning, Cincinnati must lean on its playmakers and avoid falling into long-yardage situations against a unit that thrives on disruption.

Best Bet: Ja’Marr Chase o72.5 Receiving Yards

Even with Browning under center, Ja’Marr Chase, who faces his fellow college teammate Justin Jefferson, remains the one player who can completely flip the flow of this game. His chemistry with the backup has shown up before in small doses, and with Tee Higgins drawing enough attention on the perimeter, Chase should see plenty of single coverage to exploit. Given Minnesota’s secondary has been vulnerable to explosive plays downfield, Chase’s ability to create separation and extend drives makes his yardage total a number worth backing. A handful of chunk plays could push him past the mark with room to spare.

Prediction

Ultimately, this one feels destined to come down to who can string together just a couple more plays in the second half, and in that regard, Minnesota’s defense and Jefferson’s big-play ability may prove decisive in front of a raucous home crowd. Cincinnati will compete and find its moments, but without Burrow and with too many questions in the secondary, the margin for error shrinks against a team capable of punishing every slip. For all those reasons, the Vikings will find a way to win a tight matchup at home in the battle of the backups.

Final Score: Vikings 24, Bengals 20

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Texans @ Jaguars (-1.5) (O/U: 44.5)

EverBank Stadium, Jacksonville, FL

1 pm, CBS

The Texans and Jaguars both enter this divisional clash with urgency, though the paths they’ve taken to reach this point feel strikingly different. Houston has leaned heavily on their defense to keep games competitive, with Will Anderson Jr. and Danielle Hunter consistently collapsing pockets and forcing hurried decisions, yet CJ Stroud’s offense has struggled to recapture the efficiency and explosiveness that made them such a breakout story last season. Jacksonville, meanwhile, continues adjusting to Liam Coen’s new offensive system, and while Trevor Lawrence has flashed stretches of command, shaky protection has limited his time in the pocket, while Brian Thomas Jr.’s slower start has prevented the Jaguars from consistently threatening defenses vertically. That contrast sets the stage for a game likely to be dictated by both defenses early, before the quarterbacks begin trading momentum swings as the afternoon unfolds.

Best Bet: Will Anderson Jr. o0.5 Sacks

Anderson has been one of Houston’s few constants to open the year, and his relentless motor against a Jacksonville offensive line still working to find continuity gives him an ideal setup to disrupt plays. Lawrence’s tendency to extend possessions by holding the ball invites pressure off the edge, and in a game where long third downs are likely, Anderson feels like the most dependable bet to register a sack, especially with Hunter commanding attention on the opposite side.

Prediction

Houston’s ability to generate chaos up front looks like the potential swing factor, because if Stroud can simply manage drives and avoid giving away possessions, the Texans may eventually wear down Jacksonville’s defense. The Jaguars will look to steady things by feeding Travis Etienne Jr. to establish balance, but Houston’s edge pressure combined with a secondary capable of capitalizing on hurried throws should tilt the closing moments. In a rivalry where games often hinge on just a handful of plays, the Texans appear better equipped to make those defining stops and put themselves in position for a hard-fought win on the road.

Final Score: Texans 23, Jaguars 17

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Steelers (-1.5) @ Patriots (O/U: 44.5)

Gillette Stadium, Foxborough, MA

1 pm, CBS

The Steelers are hoping to right the ship this weekend in Foxborough after a frustrating home opener, and the early-season emphasis on establishing a balanced attack will be front and center against a Patriots team eager to showcase its growth under Mike Vrabel. Aaron Rodgers remains the focal point, and his connection with DK Metcalf will be crucial as the Steelers attempt to stretch the field vertically while Jaylen Warren grinds out consistent gains on the ground, a necessary complement to keep New England’s front seven honest. Defensively, Teryl Austin’s unit will need to impose its will at the line of scrimmage, and edge rusher TJ Watt is expected to be a disruptive force, especially against a rookie quarterback who has shown flashes of dual-threat potential. With several key contributors still settling into rhythm and a high-scoring New England offense looming, the matchup promises to test Pittsburgh’s resolve in every phase.

Best Bet: Over 44.5

It might not be by much, but the number should set up for enough points to go over the game total, as both offenses feature dynamic playmakers capable of breaking the game open, while each defense has demonstrated vulnerability against the run and deep passing attacks. Expect Rodgers to test the Patriots’ secondary early, with DK Metcalf and Pat Freiermuth creating mismatches across the field, while Drake Maye spreads the ball to Rhamondre Stevenson and Stefon Diggs, mixing inside power runs with vertical shots to keep the Steelers off balance. Special teams could play a pivotal role in flipping momentum, and with Gillette Stadium often producing quick-strike scores, the over seems well within reach, particularly if the defenses continue to trade stops rather than dominate.

Prediction

This matchup will hinge on execution in critical moments, with both teams capable of mounting sustained drives yet prone to mistakes under pressure, making it a game of momentum swings and strategic adjustments. Rodgers’ ability to read the Patriots’ coverage and Maye’s athleticism in extending plays should keep the scoreboard ticking, while TJ Watt and the Steelers’ front seven will look to pressure the rookie and force quick decisions. New England’s secondary, anchored by Carlton Davis III with Christian Gonzalez likely to miss another week, will need to disrupt Pittsburgh’s rhythm without overcommitting to prevent big plays. In the end, the balance between offensive ingenuity and defensive disruption will dictate the outcome, but both teams are built to make this a high-paced, entertaining affair, and the formula of balanced offense, opportunistic defense, and timely special teams execution should shine once again.

Final Score: Steelers 27, Patriots 23

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Colts (-4.5) @ Titans (O/U: 43.5)

Nissan Stadium, Nashville, TN

1 pm, CBS

The Colts enter this matchup with the same sense of cautious optimism that has defined their season so far, blending young playmaking talent with veteran stability as they look to continue their strong start. Daniel Jones has been phenomenal after orchestrating back-to-back efficient performances under center, threading the needle on intermediate and deep throws and keeping the punter off the field while also keeping defenses honest with his mobility, and rookie tight end Tyler Warren has emerged as a reliable chain-moving threat capable of turning short completions into explosive gains. On the other side, the Titans are searching for consistency under Cam Ward, who flashes the dual-threat ability that made him a tantalizing prospect but remains error-prone in a lineup still adjusting to a new offensive philosophy. The game will likely hinge on whether the Colts can sustain long drives with balance and tempo while keeping Tennessee’s pass rush at bay, and if the Titans can prevent early momentum swings from defining the afternoon. With both teams eager to assert themselves in a pivotal divisional clash, this contest promises plenty of drama before the final whistle.

Best Bet: Tyler Warren o49.5 Receiving Yards

Warren has already emerged as one of the Colts’ most dynamic options, exploiting soft zones and creating big plays after the catch, and Tennessee’s back seven has struggled to contain athletic tight ends. If Indianapolis can sustain balanced drives and control tempo, Warren should see plenty of targets on crucial downs and in the red zone, making this prop particularly appealing. His early-season efficiency reflects both his talent and the Colts’ strategic advantage in maintaining offensive rhythm while forcing the Titans to react under pressure.

Prediction

Indy’s balanced attack and cohesive execution should keep the Titans on its heels, while Tony Pollard will be the Titans’ main avenue to generate points. Indianapolis’ defense is poised to disrupt key passing windows, and if Daniel Jones continues his high-level play, forced turnovers and sustained drives could create separation. While the Titans may make intermittent pushes, the Colts’ depth and early-season rhythm should carry them to a convincing victory. Indianapolis may not be ready to challenge the AFC’s elite just yet, but they’re trending in the right direction, and the building blocks are clearly in place for a team that could soon become one of the conference’s most dangerous, especially if Richardson blossoms into the quarterback that Steichen envisions.

Final Score: Colts 33, Titans 16

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Falcons (-5.5) @ Panthers (O/U: 44.5)

Bank of America Stadium, Charlotte, NC

1 pm, FOX

The Falcons are riding the momentum of a dominant win over the Vikings, where their defense reasserted itself as a force capable of controlling a game from start to finish, while their ground attack, led by Bijan Robinson, displayed the kind of explosiveness that can dictate tempo against any opponent. The Falcons have clearly embraced a balanced identity under Raheem Morris, blending pressure packages that challenge quarterbacks with a backfield duo that forces defenses to respect both power and finesse, and they’ll need that same combination to navigate a Carolina team looking to assert itself early in the NFC South. Despite lingering questions about wide receiver health, Atlanta’s offense has enough talent and depth to keep the Panthers honest, and the Falcons’ defensive front will aim to disrupt Bryce Young before he can settle into rhythm. Expect a fast-paced, physical game where momentum swings could hinge on a few big plays on either side of the ball.

Best Bet: Bijan Robinson o84.5 Rushing Yards

Robinson continues to be the Falcons’ offensive heartbeat, and this matchup presents a prime opportunity for him to thrive, especially against a Panthers front that has struggled to limit production after contact. Atlanta’s offensive line shapes up well to open lanes, and Robinson’s vision, patience, and explosive burst make it likely that he will repeatedly pick up chunks of yardage, keeping drives alive and forcing Carolina to play catch-up. This prop stands out not just because of Robinson’s talent but also due to the Panthers’ defensive tendencies in the run game, where assignments and angles have allowed backs to turn moderate gains into significant yardage and have resulted in their defense finishing at the bottom of rushing yards allowed. His ability to convert carries into consistent positive yardage will be central to Atlanta controlling both the clock and the flow of the contest.

Prediction

While the Panthers are capable of flashes, particularly with Young displaying the poise to make big throws late in games, they’ll be tested by a Falcons defense that can generate consistent pressure and capitalize on mistakes. Atlanta’s balance between a punishing ground game and opportunistic defense should enable them to sustain drives, respond to Carolina surges, and keep the scoreboard ticking. With Robinson leading the way and Michael Penix Jr. managing the passing attack efficiently, the Falcons are positioned to handle the pressure and impose their rhythm on the game. By the final whistle, Atlanta’s combination of calculated aggression and playmaking depth should prove decisive, setting the stage for a hard-fought contest where the Falcons leave Charlotte with the win.

Final Score: Falcons 34, Panthers 27

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Raiders @ Commanders (-3.5) (O/U: 43.5)

Northwest Stadium, Landover, MD

1 pm, FOX

This new identity for the Raiders has gotten off to an up-and-down start, but their new head coach Pete Carroll brings a veteran presence and competitive spirit back to the sidelines after his successful tenure in Seattle. He and his team are eager to prove that last week’s struggles were just a temporary setback. Their offense, led by Geno Smith and energized by Chip Kelly’s uptempo system, is capable of striking quickly, while the defensive line, anchored by Maxx Crosby and Jonah Laulu, has shown flashes of dominance that can disrupt even the league’s more versatile offenses. With the Raiders seeking to balance aggression and discipline, this matchup presents an opportunity to test whether their young roster can handle adversity in a hostile environment and make the kind of plays that define momentum in a tightly contested game.

Best Bet: Under 43.5

With both teams facing early-season wrinkles and key contributors nursing injuries, this contest feels destined for a grind-it-out battle rather than a shootout. The Commanders have shown vulnerability against tight ends and in defending quick-strike concepts, while the Raiders’ offense has struggled to maintain consistency when forced into prolonged drives. Expect the game to hinge on field position, efficient play-calling, and timely defensive stops, making the under an appealing angle for bettors who anticipate both teams leaning on calculated aggression instead of reckless passing.

Prediction

After an opening slate that exposed some cracks for both squads, this weekend provides a chance to rebound and establish identity, and this clash promises to be a tense, physical affair with each team probing for weaknesses while protecting its own. Geno’s ability to take shots downfield against a still-adapting secondary and Mariota’s mobility to extend plays will be critical with Daniels out, and the trenches, where Crosby and company meet a powerful Washington front, could very well determine the winner. Both rosters are talented, but the Raiders’ balance and opportunistic defense may be the difference, allowing them to eke out a hard-fought victory in a game defined more by calculated execution than explosive scoring.

Final Score: Raiders 23, Commanders 16

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Jets @ Buccaneers (-6.5) (O/U: 43.5)

Raymond James Stadium, Tampa, FL

1 pm, FOX

The Jets are trying to regain footing after a shaky start under Aaron Glenn, and things won’t get any easier as they go up against a coach that the franchise previously fired in Todd Bowles, whose Buccaneers team looks hungry even with some impact guys out. With Justin Fields sidelined, Tyrod Taylor steps in to stabilize an offense that has flashes of big-play potential but still needs cohesion along the line and at skill positions. The Jets’ young receiving corps, led by Garrett Wilson, will have to carve out space against a Buccaneers defense that thrives on versatility and disruption, while Breece Hall and Braelon Allen look to establish balance in the backfield. Tampa Bay enters the contest with confidence from two consecutive wins, even while navigating injuries along the offensive line and secondary, and Baker Mayfield’s command of a timing-based attack will be critical in exploiting mismatches in the Jets’ reshaped defense. The game has all the ingredients for a battle of patience and poise, where each mistake is magnified and the team that can execute in the trenches is likely to dictate the narrative.

Best Bet: Buccaneers -6.5

This spread has settled near a touchdown in part because of the advantage they hold in both experience and situational awareness. Tampa Bay’s offense, even with Tristan Wirfs and Chris Godwin questionable, has the personnel and rhythm to pressure Taylor and force the Jets into difficult decisions on third down. On the defensive side, Bowles’ front seven can pin their ears back and disrupt the timing of the Jets’ backfield, which lacks Fields’ mobility, leaving Taylor vulnerable under duress. For those looking for a sharp angle, backing the Buccaneers to cover is appealing, particularly in a game where home-field energy and mid-level turnovers could swing momentum early. The matchup favors the team with a more reliable quarterback and fewer moving pieces in key roles, making Tampa Bay an attractive option for the spread.

Prediction

The Bucs are likely to control this contest through methodical drives and opportunistic defense, challenging the Jets to respond consistently while adjusting to a quarterback change and ongoing growing pains. Baker Mayfield’s ability to navigate pressure, paired with a rushing attack that can convert short-yardage situations, should keep Tampa Bay ahead in crucial moments. Despite a valiant effort from Garrett Wilson and New York’s dynamic backfield, the Jets may struggle to sustain long possessions against a disciplined, experienced Bucs unit. For Tampa Bay, it’s another gritty, unpolished performance, but the kind that demonstrates when games tighten in the final minute, they have the toughness and resolve to come out on top.

Final Score: Buccaneers 26, Jets 17

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Packers (-7.5) @ Browns (O/U: 41.5)

Huntington Bank Stadium, Cleveland, OH

1 pm, FOX

The Packers are looking to build on its early momentum, and this matchup against Cleveland provides another test of consistency for both sides of the ball. Green Bay’s offense, guided by Jordan Love, has shown flashes of precision, though running the ball effectively has been a challenge against disciplined fronts, and Josh Jacobs will need to mix patience with his trademark bursts to keep drives alive. On the defensive side, Micah Parsons has continued to dominate up front, generating chaos and forcing quarterbacks into hurried decisions, and he won’t be the only player in Green Bay’s front seven capable of flipping the field with a key sack or tackle for loss. Expect the game to be a chess match between the Packers’ balanced scheme and a Browns defense that has already shown it can be suffocating when disciplined.

Best Bet: Under 41.5

Cleveland, for its part, will lean heavily on a controlled approach to keep the Packers’ pass rush in check, and rookie Quinshon Judkins is poised for a more significant workload as the team looks to establish a consistent ground attack. Joe Flacco’s ability to manage the game and avoid costly mistakes will be tested by Green Bay’s relentless pressure, and the Browns’ offensive line will be tasked with neutralizing threats like Karl Brooks and Lukas Van Ness. Given both teams’ recent tendencies to struggle in finishing drives and the early-season defensive improvements on each side, the total points are likely to stay below expectations, making the under the most appealing play of the weekend.

Prediction

Despite the Browns’ home-field advantage and the promise of an emerging running game, Green Bay’s balanced attack and disruptive front seven should be the difference in this matchup. Jordan Love’s poise and the Packers’ ability to sustain drives, combined with a defense that can dictate the tempo, create a favorable environment for Green Bay to control both possession and momentum. The Browns may manage some positive sequences on offense, but turnovers and a lack of consistent pressure on Love could make it difficult to stay within striking distance. Although there will be some flashes from the young talent from the Browns, the game will be defined by methodical execution and opportunistic defensive plays, leaving Green Bay as the side to trust more, even on the road.

Final Score: Packers 24, Browns 13

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Rams @ Eagles (-3.5) (O/U: 44.5)

Lincoln Financial Field, Philadelphia, PA

1 pm, FOX

One of the biggest matchups of the weekend will be present in Philadelphia again when the Eagles host the Rams in a NFC Divisional Round rematch from last year’s postseason, and the Rams are looking to build onto a strong 2-0 start, bringing Matthew Stafford’s leadership and a dynamic receiving duo of Davante Adams and Puka Nacua to a matchup where every yard will matter. On the other side, the reigning champions are hungry to prove that their Super Bowl triumph wasn’t a fluke, with Jalen Hurts orchestrating a physical, methodical attack behind Saquon Barkley’s punishing running style. Both teams have shown early-season discipline and toughness, and this contest promises to be a chess match between McVay’s creative offensive schemes and Sirianni’s balanced, aggressive approach. Turnovers, key third-down conversions, and situational execution will likely determine the outcome as both squads seek to assert themselves before the season’s midpoint.

Best Bet: Jalen Hurts Anytime TD

Hurts continues to be a force both through the air and on the ground, and with the Rams’ front seven focused on containing Barkley, Philadelphia’s quarterback is likely to find open lanes near the goal line and get the Tush Push that he needs to find the end zone for the third week in a row. The Eagles’ offensive line has dominated early, carving out space for the Tush Push and creating opportunities in short-yardage situations, and Hurts has a knack for turning those glimpses of daylight into scoring plays. Expect him to take advantage of defensive overcommitments, whether slipping past a closing linebacker or rolling out for a red-zone throw, making an anytime touchdown the most reliable prop for this matchup.

Prediction

Both teams are disciplined, physical, and capable of explosive plays, which sets the stage for a tightly contested game with momentum swinging back and forth. Barkley will churn out tough yards between the tackles, while Stafford looks to stretch the field and keep the Eagles’ defense honest. The battle in the trenches, coupled with the playmaking ability of Adams, Nacua, Hurts, and Barkley, will make for a dramatic afternoon of football that keeps fans on edge until the final whistle. The win wasn’t perfect, but it was complete, and it reaffirmed that the defending champs still know how to handle the biggest stages.

Final Score: Eagles 24, Rams 19

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Saints @ Seahawks (-7.5) (O/U: 41.5)

Lumen Field, Seattle, WA

4:05 pm, CBS

The Seahawks earned a strong road win in Pittsburgh last weekend, and they are going to give this struggling Saints team all that they can handle. Spencer Rattler is still searching for his first career road win and will need to maintain composure amid the deafening crowd as the Saints attempt to execute Kellen Moore’s motion-heavy offensive schemes, leaning on Alvin Kamara’s versatility and Juwan Johnson’s consistent reliability. Meanwhile, the Seahawks, energized by home-field advantage and a disruptive pass rush are prepared to test the Saints’ inexperienced offensive line and force mistakes in key moments, and Seattle’s own balanced attack with Sam Darnold distributing to Cooper Kupp and Jaxon Smith-Njigba ensures that New Orleans will face a multi-dimensional threat in all areas of the field. Both teams are still shaping their identities, but the stakes of a pivotal NFC matchup and the desire to avoid an 0-3 start add urgency to every snap.

Best Bet: Alvin Kamara o3.5 Receptions

Kamara’s role as the offensive pivot in a committee-heavy backfield makes him a dependable source of receptions, and the Seahawks’ willingness to crowd the line against the Saints’ young front creates opportunities for quick passes and checkdowns, which should result in a lot of production for a guy who has covered this line in every game since September 2024. Whether Rattler opts to attack the intermediate zones with tight ends and running backs or relies on Kamara to bail him out on third down, he remains the most consistent conduit for the Saints to move the chains and avoid being pinned by Seattle’s home crowd. Expect Kamara to see multiple targets in every quarter, particularly in high-leverage situations where short-yardage gains could flip momentum, and his ability to find space in the Seahawks’ nickel-heavy defense gives him a clear path to exceeding three receptions.

Prediction

This game is likely to be defined by Seattle’s front seven dictating the pace and New Orleans struggling to sustain drives without a fully established quarterback rhythm, and the noise and strategic complexity at Lumen Field will exacerbate the Saints’ growing pains. Kamara’s contributions will be one of the few constants, giving New Orleans brief flashes of forward movement, while Darnold and the Seahawks’ passing attack are poised to exploit mismatches and test the Saints’ coverage units repeatedly. If the young Saints offensive line falters under sustained pressure, and Rattler’s poise is challenged by coordinated blitzes, the Seahawks should be able to build an early lead and maintain control, which is exactly what I think will happen. Seattle cruises for four quarters, and they move to 2-1 on the year while the Saints continue struggling tremendously, especially at the quarterback position.

Final Score: Seahawks 30, Saints 10

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Broncos @ Chargers (-2.5) (O/U: 45.5)

SoFi Stadium, Inglewood, CA

4:05 pm, CBS

This matchup promises a clash that could set the tone for both teams’ ambitions to take the Chiefs’ throne at the top of the AFC West, and with two old NFC head coaches with Super Bowl experience, these teams are talented enough to even contend for the AFC crown as well. The Broncos are coming off a narrow loss in Indianapolis that showcased both their potential and lingering inconsistencies, particularly on defense, while the Chargers enter this matchup riding momentum and a home-field advantage that could amplify their physical style. With Bo Nix looking to build on his growing chemistry with key targets like Courtland Sutton and Marvin Mims Jr., Denver will aim to keep Justin Herbert off rhythm and force a few critical errors, but Los Angeles’ offensive balance and offensive line depth present a formidable challenge. Expect the tempo to swing back and forth as each squad tests the other’s adjustments, and with stakes already high in this divisional battle, both teams are likely to play with a mix of aggression and caution.

Best Bet: Chargers -2.5

It will be close, but with the number so low, the Chargers should still find a way to cover this number, which will hinge on controlling the line of scrimmage and dictating the pace while also having the home crowd behind them. Without Khalil Mack, the Chargers’ edge rush loses its most fearsome presence, but other defenders like Tuli Tuipulotu and Da’Shawn Hand can still generate pressure and disrupt Nix’s timing. On offense, Justin Herbert’s ability to distribute the ball efficiently to Keenan Allen, Ladd McConkey, and Quentin Johnston while mixing in the ground game with Omarion Hampton and Najee Harris should keep Denver’s defensive front honest. Meanwhile, the Broncos’ strategy will likely rely on creative blitz packages and limiting explosive plays, but consistency in execution will be critical for keeping this game within reach. Considering the Chargers’ home advantage, offensive firepower, and ability to adapt on both sides of the ball, the line leans toward Justin Herbert and his team maintaining control late in the game.

Prediction

This matchup is poised to be a compelling back-and-forth, with both offenses showing the ability to move the ball effectively, but ultimately, the Chargers have the pieces to tilt the balance in their favor. While Denver’s Nix is developing into a capable playmaker and his skill position weapons offer genuine threats, LA’s home-field energy and deeper roster give them an edge in key situations. Expect turnovers and big-yard plays to play a decisive role, and the battle in the trenches should dictate which team sustains drives and keeps momentum. When the dust settles, the Chargers’ strong play on both sides of the ball should allow them to leave Inglewood with another narrow divisional victory.

Final Score: Chargers 26, Broncos 21

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Cardinals @ 49ers (-2.5) (O/U: 45.5)

Levi’s Stadium, Santa Clara, CA

4:25 pm, FOX

The Cardinals have a much clearer direction and growing optimism surrounding their young core after two years of foundational work under head coach Jonathan Gannon, and their early success this season has injected energy into a roster still defining its identity. Kyler Murray’s ability to improvise and extend plays will once again be the key storyline, especially against a 49ers defense anchored by Fred Warner and Nick Bosa, who will look to make him uncomfortable in the pocket. On the other side, San Francisco has been trying to rediscover its rhythm under Kyle Shanahan with Klay Kubiak adding fresh wrinkles to the offense, and the emergence of Christian McCaffrey as both a ground and receiving threat could test a Cardinals front seven still adjusting to new alignments. Matchups in the trenches and how each team handles high-leverage third downs may ultimately dictate the tempo, while momentum-swinging plays from the skill position players will likely decide which squad seizes the edge in a tight contest.

Best Bet: Cardinals ML

The Cards’ early-season resilience makes them an intriguing pick to steal a road win, and betting on them feels even more justified given the fact that they’re the underdog against a banged up Niners squad. Murray’s dual-threat capability combined with a balanced backfield featuring James Conner and Trey Benson gives Gannon’s offense multiple ways to generate chunks of yardage even if the passing attack faces tight coverage. San Francisco will rely heavily on McCaffrey and Ricky Pearsall to spark drives, but the Cardinals’ rotation of versatile linebackers and defensive backs is capable of slowing down big-play opportunities and forcing mistakes at key moments. This clash between a young, upward-trending offense and a disciplined, adaptable defense sets the stage for a contest where the Cardinals’ ability to manage the clock and convert critical third downs may ultimately tip the scales in their favor.

Prediction

This matchup promises a thrilling mix of improvisational offense and disciplined defense, with neither team likely to dominate for long stretches. Expect explosive runs from Murray and Conner, countered by Bosa and Warner’s relentless pursuit, and a receiving battle where Marvin Harrison Jr. and McCaffrey could steal the spotlight. San Francisco’s offensive creativity will test Arizona’s secondary, but a few timely stops and clutch conversions by the Cardinals should keep them within striking distance and allow them to edge past the 49ers in a game that may come down to the final possession. At 2-0, the Cardinals are on a mission to soar to the top of this wide-open division, and they are going to take down a vulnerable San Francisco roster.

Final Score: Cardinals 20, 49ers 17

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Cowboys (-1.5) @ Bears (O/U: 50.5)

Soldier Field, Chicago, IL

4:25 pm, FOX

The Cowboys won what was a potential Game of the Year candidate last week over the Giants to earn their first win of 2025, and with a new rhythm that their offense has finally found under Brian Schottenheimer, their matchup with the Bears could reveal just how quickly they can keep that rhythm going. Dak Prescott’s start to the season has been a masterclass in poise under pressure, as he continues to connect with CeeDee Lamb and George Pickens downfield while balancing a ground attack led by Javonte Williams. The Cowboys’ defense, on the other hand, faces a tough test against Caleb Williams and a Bears passing game that has flashed potential despite last week’s struggles, and the chess match between defensive coordinator Matt Eberflus returning to Soldier Field and his former team adds a fascinating subplot to what should be a hard-fought and high-energy divisional duel.

Best Bet: Cowboys -1.5

Expect this game to hinge on execution in the trenches and the ability of both quarterbacks to sustain drives against defenses still adjusting to new schemes. Prescott’s efficiency on third downs and under pressure gives Dallas a slight edge in sustaining momentum, while Chicago’s young receiving corps, particularly Rome Odunze, could create explosive plays if the offensive line provides enough time. The total of 50.5 suggests both teams have the firepower to put up points, but with the Cowboys’ offense humming and the Bears still finding their footing under Ben Johnson, Dallas covering the small spread appears most likely.

Prediction

This matchup shapes up to be a high-scoring, back-and-forth battle that keeps fans on the edge of their seats, with both teams leaning on their playmakers to gain an advantage at key moments. The Bears will surely expose a very weak Dallas secondary with plenty of solid options for Williams to work with, but their defense is pretty vulnerable as well. At the end of the day, the Cowboys’ balanced attack and steady quarterback play should allow them to take care of business and hold off the Bears late, securing another hard-fought victory in Chicago.

Final Score: Cowboys 38, Bears 31

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Chiefs (-6.5) @ Giants (O/U: 45.5)

MetLife Stadium, East Rutherford, NJ

8:20 pm, NBC/Peacock

The Chiefs are looking to right the ship after a rough start to the season, and this primetime clash offers a perfect stage for Patrick Mahomes and the offense to regain their footing. While the scoreboard has yet to reflect their full potential, the Chiefs’ dynamic playmakers remain capable of explosive sequences, particularly in a matchup against a Giants defense that has shown moments of vulnerability along the front and in coverage. For the Giants, the spotlight will shine on Russell Wilson and his supporting cast, including Malik Nabers as they try to extend the momentum from last week, balancing the promise of their high-powered passing attack against a Kansas City unit desperate for a statement. Both squads enter this one aware that early-season narratives can shape confidence for the weeks ahead, and with an emotional crowd and national attention, expect the intensity to remain high from the first snap through the final whistle.

Best Bet: Wan’Dale Robinson o4.5 Receptions

With the Giants’ passing attack expected to lead the way with them likely trailing for most of the game, slot receiver Wan’Dale Robinson is positioned to see plenty of targets, particularly on intermediate routes that exploit matchups over the middle of the field. His quickness and route precision make him the natural safety valve when Wilson faces pressure, and with New York likely to lean on short-to-medium passes to control tempo, he should reach five catches, especially considering he reached double-digits in targets last weekend against the Cowboys. Robinson’s involvement is not only a key for fantasy players but also a barometer for how effectively the Giants can sustain drives against a defense hungry for a turnover.

Prediction

Expect a lower-scoring game that swings with momentum and features big plays from both quarterbacks, yet the edge will tilt toward the Chiefs’ ability to impose structure and capitalize on a few key mistakes. Mahomes’ improvisational skill and connection with Travis Kelce and the other receivers, combined with the defense’s aggressiveness and ability to force key turnovers, should be enough to tilt the outcome in their favor. While the Giants will threaten and keep the score close with their pass rush, the Chiefs will earn their first win of 2025.

Final Score: Chiefs 24, Giants 16

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Monday, September 22

Lions @ Ravens (-4.5) (O/U: 53.5)

M&T Bank Stadium, Baltimore, MD

8:15 pm, ABC/ESPN

Finally, we cap off Week 3 with a marquee NFC vs. AFC clash as the Lions travel to Baltimore for a game that has Game of the Year potential written all over it, and it promises a collision of two teams with high-octane offenses and opportunistic defenses. Detroit comes in with confidence from a dominant home win over the Bears and their former offensive coordinator Ben Johnson, but this matchup demands a matching of Baltimore’s physicality and speed while minimizing mistakes against a Lamar Jackson-led attack that thrives on chaos. With the Ravens looking to assert themselves early at home, this contest carries all the intrigue of a heavyweight bout, from the trenches to the passing game, and every possession could swing momentum dramatically as both teams try to establish their identity.

Best Bet: Over 53.5

It’s an extremely high number for any NFL game, but given the offensive firepower on display, from Jared Goff’s sharp accuracy to Baltimore’s backfield brilliance, this matchup has all the ingredients for a shootout. Detroit’s one-two punch at running back and quick-strike passing attack will test a Baltimore defense that has shown vulnerability against fast-paced, multiple-receiver sets, while the Ravens’ own ground and pound assault, led by Jackson and Derrick Henry, will be sure to keep the Lions’ front seven ready for anything out of one of the best rushing attacks in the NFL. Recent trends out of these two offenses suggest that when they meet, points come quickly, making the over the most appealing angle for bettors willing to ride the scoring wave.

Prediction

Expect a game defined by momentum swings and highlight-reel plays, with big completions and explosive runs keeping fans on edge until the final minutes. Detroit’s aggressiveness and methodical execution will allow them to hang around, but Baltimore’s home-field advantage, paired with Jackson’s dual-threat capabilities and a defense that excels at timely stops, should ultimately lift them up for their second win and first key victory of the season. However, even though the Ravens will give this Detroit team everything they can handle, the Lions will leave Baltimore with a statement that coordinators don’t define this team’s true talent.

Final Score: Ravens 35, Lions 31

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Make sure to stay tuned this weekend as we learn a little more about some of the top teams in a hefty Week 3 slate to keep things rolling this season!