Week 2 in college football always feels like the sport’s first real test of patience. The wild energy of opening weekend has settled, the biggest matchups are behind us, and now we’re left trying to figure out what was real and what was just noise. Teams that looked like juggernauts in Week 1 now have to back it up against opponents who have film to study, and the programs that stumbled early get their first chance to show whether those struggles were flukes or signs of deeper problems. The headliner, of course, is Michigan heading to Norman for a showdown with Oklahoma, a game that will give Bryce Underwood his first taste of a truly hostile road environment while Brent Venables tries to prove the Sooners can go toe-to-toe with one of the Big Ten’s best. Beyond that, rivalries, tricky road trips, and a handful of under-the-radar tilts will shape the weekend in ways we won’t appreciate until the dust settles. Week 2 might not have the same shine as opening weekend, but it’s often where the season really starts to separate contenders from everyone else. With that in mind, let’s dive into the previews and predictions for this weekend’s slate:

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Friday, September 5

James Madison @ Louisville (-12.5) (O/U: 55.5)

L&N Federal Credit Union Stadium, Louisville, KY

7 pm, ESPN2

While most of the spotlight will be on the Kansas City Chiefs and Los Angeles Chargers on Friday night when they meet in Brazil, Jeff Brohm’s Cardinals will be another exciting watch as well when they welcome their first of three Friday opponents for this season: a James Madison program that has quickly transitioned from FCS powerhouse to consistent Group of Five contender. The Cardinals have reloaded offensively with USC transfer Miller Moss taking over at quarterback, and he has the benefit of a strong backfield led by Isaac Brown and Duke Watson, who combined for nearly 1,800 yards on the ground last season and are the heartbeat of this attack. Chris Bell and Caullin Lacy provide reliable options on the perimeter, while the offensive line, though reshuffled, should still give Moss the protection needed to open up Brohm’s vertical passing game. The defense, anchored by linebackers TJ Quinn and Stanquan Clark, has a chance to dictate the tempo if the front seven contains James Madison’s stable of backs. The Dukes, meanwhile, arrive off a hard-fought opening win where they leaned heavily on their run game, piling up over 270 rushing yards with explosive plays from former North Carolina back George Pettaway and Wayne Knight. With quarterbacks Alonza Barnett III and Matthew Sluka combining for only 145 yards through the air, the Dukes will need more balance if they want to threaten an ACC defense that thrives on forcing one-dimensional play.

Best Bet: Louisville -12.5

The line may look hefty at first glance, but Louisville covering a two-touchdown spread is my favorite play of the weekend, largely because the matchup tilts toward the Cardinals in areas that matter most. James Madison’s offense is built to grind opponents down with the run behind the legs of Barnett and Pettaway, but Louisville’s defensive strength lies in its linebacking corps and edge speed, which makes it difficult to imagine the Dukes consistently churning out big gains the way they did in Week 1. If they’re forced into passing situations, Barnett and Sluka have shown just a little that they can stretch the field against Power Five competition, especially Sluka during his time with UNLV after he led the Rebels to wins over Houston and Kansas, but he likely won’t be on the field very much with Barnett ahead, who doesn’t have that same big game experience, those squads from last year aren’t nearly as good as this Louisville squad. Moss should find his footing quickly with Brohm dialing up tempo and spreading the ball around, which will only open more lanes for Brown and Watson to control the game on the ground. When you add in Louisville’s depth at home and the ability to wear opponents down with both physicality and speed, the double-digit cushion becomes far less intimidating. James Madison has shown fight since entering the FBS, but the jump in class here feels steep, and Louisville’s balance on offense and discipline on defense should allow them to clear the number with some room to spare.

Prediction

For James Madison, the path to keeping this game close requires limiting possessions, establishing the run early, and finding a way to flip momentum with turnovers, but all three will be tall orders against a Louisville team that has quietly built one of the ACC’s most complete rosters. The Cardinals have enough firepower to play fast if the game script calls for it, yet they can also pound away behind Brown and Watson if they need to wear the Dukes down, giving Brohm the flexibility to adapt and stay in control. JMU’s defense showed flashes in its opener with three interceptions, but those forced mistakes don’t translate the same way against Moss, who is more experienced and steadier under pressure. The deeper the game goes, the more Louisville’s advantages in the trenches and depth of playmakers should begin to show, and while the Dukes may land an early punch or two with their ground game, sustaining it against an athletic defense is another story. By the fourth quarter, it’s hard to envision James Madison matching Louisville’s pace or firepower, and that separation will underline why the Cardinals are viewed as legitimate ACC contenders while the Dukes still remain one of the tougher Group of Five challengers.

Final Score: Louisville 38, James Madison 20

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Saturday, September 6

#11 Illinois (-3.5) @ Duke (O/U: 49.5)

Wallace Wade Stadium, Durham, NC

Noon, ESPN

From the Dukes to Duke, the Blue Devils will host Illinois in one of my favorite matchups heading into the weekend, and we get to find out how much of a contender and threat each team can potentially be in their roads as true dark horse contenders in their respective conferences. The Fighting Illini head into Durham with sky-high expectations after a ten-win season in 2024 and ride a wave of optimism that hasn’t been seen in Champaign for over two decades with legitimate aspirations of pushing into the Playoff conversation. Head coach Bret Bielema has built a program defined by toughness in the trenches and consistency in execution, and with 18 starters back, this year’s Illini are as battle-tested as any team in the B1G. Quarterback Luke Altmyer returns for his third season under center, and while he’ll be adjusting to a reshuffled wide receiver room, the emergence of Hank Beatty and Justin Bowick and upside of guys like Malik Elzy offer plenty of promise. Supporting them is one of the deepest offensive lines in the country, a group that will pave the way for backs Aidan Laughery and Kaden Feagin to provide both speed and power. Duke, meanwhile, faces a season of transition under new head coach Manny Diaz, but the program continues to prove resilient. The Blue Devils made a splash by securing Tulane transfer Darian Mensah at quarterback, and his ability to extend plays, along with one of the best receiver rooms that the Blue Devils have had in a while, will be crucial against a relentless Illinois defense. The stage is set for a physical, chess-match battle in Durham where both programs can make an early statement about their direction in 2025.

Best Bet: Aidan Laughery o50.5 Rushing Yards

While there are a handful of intriguing angles in this matchup, the Illinois rushing attack looks like the clearest place to target props, and Aidan Laughery remains the best value play. Laughery is positioned to get the bulk of the open-field opportunities thanks to his speed and vision, and behind one of the B1G’s best offensive lines, he should have plenty of chances to break runs into the second level. Still, he isn’t the only Illini back worth monitoring. Kaden Feagin, the 6-foot-3, 250-pound bruiser, is a prime candidate to cash an anytime touchdown given his role in short-yardage and red-zone situations, and his rushing total also feels playable if Illinois leans heavily on their ground game as expected. Quarterback Luke Altmyer’s passing under also stands out, as Duke’s defensive scheme is built around generating pressure and forcing contested throws against wideouts. The Blue Devils surrendered over 160 rushing yards to Elon last Thursday, which only reinforces the idea that Illinois can lean on its elite run blocking and talented backfield tandem to control the game. Laughery should get a larger chunk of the action, and while the Illini have multiple ways to attack on the ground and possess balance that makes their rushing props especially appealing, he’s the safer option here.

Prediction

This game will be a grind-it-out clash where Illinois’ depth and physicality eventually prove decisive, but Duke is far too talented to be dismissed outright. The Blue Devils will attempt to disrupt rhythm early by leaning on their pass rush and forcing Altmyer to make tight throws to a still-developing receiver group, and Darian Mensah has the playmaking ability to turn broken plays into momentum-shifting drives. However, Illinois has the kind of defense that thrives in these scenarios, anchored by All-B1G linebacker Gabe Jacas, who should cause havoc in the backfield, and supported by a secondary that ranks among the deepest in the conference. The Illini are unlikely to allow Duke to sustain possessions consistently, and as the game wears on, the cumulative effect of Illinois’ run game will begin to show. Laughery’s quickness and Feagin’s power form a complementary backfield that should find success late in drives, extending possessions and keeping Duke’s offense on the sideline. By the fourth quarter, Illinois’ ability to dominate the line of scrimmage on both sides of the ball should allow them to grind out a win, reaffirming their status as one of the nation’s more physically dominant and playoff-capable teams.

Final Score: #11 Illinois 24, Duke 17

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Iowa @ #16 Iowa State (-3.5) (O/U: 41.5)

Jack Trice Stadium, Ames, IA

Noon, FOX

This year’s Cy-Hawk matchup in Ames promises another defensive grind, but with plenty of storylines that could swing the game one way or another. Iowa enters under Kirk Ferentz for his 27th season, maintaining the program’s trademark consistency and physical identity, leaning heavily on a ground game orchestrated by Xavier Williams and Terrell Washington Jr. with Kamari Moulton now on the sideline dealing with an injury, while Mark Gronowski provides limited but potentially efficient passing options. Defensively, the Hawkeyes boast a veteran front seven with Ethan Hurkett, Max Llewellyn, and Aaron Graves forming a formidable interior, complemented by a secondary anchored by Xavier Nwankpa and TJ Hall. Iowa State, meanwhile, remains one of the Big XII’s most dangerous teams, led by Rocco Becht, who has combined for nearly 500 yards and five touchdowns through the air in just two games, while the tandem of Charlie Hansen and Abu Sama III offers a balanced rushing attack capable of controlling tempo. The Cyclones’ defense, guided by Jon Heacock, returns key contributors across the line and in the secondary, including Jeremiah Cooper and Jontez Williams, allowing them to pressure the quarterback and limit big plays. Expect a hard-nosed battle featuring methodical drives, time-of-possession strategies, and an emphasis on the run game, as both teams look to assert control and set the tone for the remainder of their seasons.

Best Bet: Under 41.5

Surely these offenses can put up more points than in previous Cy-Hawk Cup matchups, but man, I have a hard time believing it. 41.5 is a very small game total in any college football game, but this isn’t anything new for Iowa and Iowa State, as they’ve gone under this number in each of their last three meetings and five of their last six meetings. Iowa’s offense, while more balanced than in previous seasons, is still heavily run-focused, as the Hawkeyes averaged 5.8 yards per carry against Albany and spread the workload across multiple backs, limiting explosive plays while controlling possession. Iowa State’s offense, although potent in the passing game through Becht and his receivers, will likely face Iowa’s disciplined front, slowing tempo and reducing scoring chances. The combination of stout defenses and a shared emphasis on running the football should produce sustained drives with limited quick strikes. Even with the Cyclones’ home-field advantage and depth in skill positions, Iowa’s capacity to eat the clock with multiple backs and an improving offensive line makes it unlikely either team will surpass this total comfortably. Penalties, turnovers, and missed field goals could also play a role in suppressing the scoreboard, reinforcing the under as a prudent wager. Considering the historical context and team tendencies, it’s difficult to envision a high-scoring shootout in Ames.

Prediction

This game will be an all out slugfest, and it’s going to be marvelous. Iowa’s offensive line and linebackers will look to control the trenches and limit explosive runs, but Iowa State’s versatile rushing tandem of Carson Hansen and Abu Sama III, combined with Rocco Becht’s efficient passing, will challenge every level of the Hawkeyes’ defense. Expect the Cyclones to methodically attack in all three phases, mixing sustained drives with timely passes and well-designed runs to dictate tempo and keep Iowa off balance. Special teams could also play a decisive role, as field position battles and key punts or returns may swing momentum in a game where every yard matters. The in-state stakes only amplify the intensity, as both teams understand the pride and history on the line, making mistakes far more costly than usual. While Iowa has a veteran defense and a productive ground game, the Hawkeyes may struggle to consistently generate game-changing plays without turnovers or third-down stops. Iowa State’s offense, with more depth, experience, and efficiency, is likely to maintain the edge throughout, controlling the clock and sustaining drives even if the score appears tight, leaving them with the upper hand in this fierce, low-scoring showdown.

Final Score: #16 Iowa State 19, Iowa 16

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Baylor @ #17 SMU (-2.5) (O/U: 64.5)

Gerald J. Ford Stadium, Dallas, TX

Noon, The CW Network

After looking into a matchup that should feature one of the season’s lower-scoring affairs, we now transition into one that will give fans almost no defense and all offense, as Baylor hopes to avenge their loss to Auburn last week in a marquee Week 1 showdown and take on SMU in Dallas in Week 2. The Bears enter the contest looking to continue their impressive turnaround under Dave Aranda, leaning on quarterback Sawyer Robertson to orchestrate a versatile passing attack featuring top targets Josh Cameron, Michael Trigg, and Kobe Prentice. The ground game will also play a key role, with 1,000-yard rusher Bryson Washington taking on an increased workload in Dawson Pendergrass’s absence, providing balance and explosive potential. SMU, meanwhile, counters with dual-threat quarterback Kevin Jennings leading a dynamic offense built around Romello Brinson and Jalen Cooper, complemented by sophomore backs Derrick McFall and transfers TJ Harden and Chris Johnson Jr. Both defenses are capable of creating big plays, with Baylor’s secondary anchored by Devyn Bobby and Caden Jenkins, while SMU relies on safeties Ahmaad Moses and Isaiah Nwokobia and an opportunistic front seven to force turnovers. The game will come down to which team can sustain drives, protect the football, and capitalize on momentum swings in a high-speed, in-state battle that promises fireworks from start to finish.

Best Bet: Baylor ML

Yes, I know I picked Baylor to win last week in an upset, and they lost. Yes, I understand that this team is playing a ranked team this time around on the road. However, I’m not giving up on the Bears just yet, and I think they are going to play with an even bigger purpose in an in-state matchup that promises to provide plenty of offensive fireworks for four quarters. SMU is on a path to revenge from last year’s heartbreak, but while they are at home and playing against a team that they can score with blow for blow, I think they come up just a few plays short and suffer their first defeat on a slate that promises to be more difficult than last year’s for the Mustangs, and it comes down to trust in Sawyer Robertson and what Dave Aranda has assembled in Waco. The Bears’ offense is balanced and deep, with Bryson Washington carrying a heavier load, Josh Cameron, Kole Taylor, and Michael Trigg stretching the field, and Robertson poised to make quick reads in key moments. SMU’s defense is talented, but Baylor’s ability to mix short passes, explosive throws, and efficient runs gives them an edge in sustaining drives and controlling tempo. Momentum, red-zone execution, and composure in a hostile environment all tilt in Baylor’s favor, especially if some of SMU’s stars like RJ Maryland and Alexander Kilgore are unable to play, making them the side I trust to emerge victorious when the dust settles.

Prediction

This matchup will likely be decided by which quarterback can make the biggest impact in a high-stakes, early-afternoon clash. Kevin Jennings is poised for a huge game, using his dual-threat ability and poise to challenge Baylor’s defense and generate explosive scoring opportunities. Bryson Washington gives the Bear offense more than enough balance, but still, Sawyer Robertson’s arm and deep-ball accuracy could prove even more decisive, giving them the potential to create the game-changing plays that swing momentum in critical moments. Expect a back-and-forth battle throughout, with both teams answering each other’s scores and keeping the crowd in Dallas fully engaged from start to finish. As the game approaches its climax, Robertson’s ability to connect on timely throws and orchestrate Baylor’s passing attack with precision should allow the Bears to make a few pivotal plays, stunning the Mustang faithful and tilting the outcome in their favor. While Jennings will keep SMU within striking distance and force tense, high-leverage moments, Baylor’s combination of arm strength, offensive rhythm, and situational execution gives them a slight edge in this in-state showdown, setting the stage for what should become an instant classic in Dallas.

Final Score: Baylor 38, #17 SMU 34

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#20 Ole Miss (-9.5) @ Kentucky (O/U: 50.5)

Kroger Field, Lexington, KY

3:30 pm, ABC

One year after losing to Kentucky in a game that virtually knocked Ole Miss out of last year’s CFP field, the Rebels are ready to seek their revenge on the Wildcats as they face off in Lexington this time around. Lane Kiffin’s squad arrives with confidence after a dominant season opener, with 19-year-old Austin Simmons stepping in at quarterback and already showing poise in leading a high-powered SEC offense. The Rebels’ skill positions offer a mix of explosiveness and balance, highlighted by Simmons’ strong arm, reliable wideouts like Harrison Wallace III and Caleb Odom, and versatile backs Kewan Lacy and Logan Diggs who can both move the chains and break big plays. On the defensive side, Ole Miss returns a stout run defense while incorporating new contributors along the defensive line, at linebacker, and in the secondary, with an eye toward maintaining the SEC’s top-ranked turnover production from last season. Kentucky, meanwhile, enters with motivation to bounce back from a disappointing 2024 campaign, leaning on transfer Zach Calzada at quarterback and a revamped receiving corps led by Kendrick Law to generate offense, and with key losses on defense, mainly across the front and secondary, Brad White’s unit will face an early test in containing a disciplined and versatile Rebel attack. This matchup promises to be a fiercely competitive, high-stakes contest, with momentum likely to swing multiple times as Ole Miss looks to assert control while Kentucky fights to reclaim its home-field advantage.

Best Bet: Kewan Lacy o68.5 Rushing Yards

Kewan Lacy is a name that not a ton of people know about yet, but they soon will. The Missouri transfer had an impressive first showing in last week’s game, running for over 100 yards and recording three touchdowns in the process. Kentucky’s defense might be miles better than Georgia State’s, but as long as the Rebels stay out in front, Lacy will get a pretty busy workload. The Wildcats have a more experienced front than Georgia State, yet Lacy’s combination of size, vision, and burst makes him a dangerous weapon capable of creating explosive plays. Ole Miss’ offensive line is expected to open lanes and sustain drives, keeping Simmons upright while allowing Lacy to shoulder a significant portion of the offensive responsibility. If Kentucky keys in on the passing game, it could open additional opportunities for designed runs and goal-line touches, increasing his chances to exceed the rushing total. Lacy’s early-season form, coupled with the Rebels’ tendency to feed their most productive backs in favorable matchups, makes this a compelling over, particularly in a game where Ole Miss seeks to assert control and maintain offensive rhythm. Whether pounding the ball between the tackles, exploiting broken plays, or breaking into the secondary for a long score, expect Lacy to remain a focal point throughout, with his legs serving as a difference-maker in keeping drives alive and helping the Rebels dictate tempo.

Prediction

While Kentucky has the home field advantage this time around following a massive win in Oxford last year, I don’t think lightning strikes twice here. Ole Miss is hungry and motivated, and I think they’ll show that in pretty convincing fashion. Kentucky puts up a score late, but the Rebels lay the hammer down and dominate for much of the contest. Austin Simmons is still trying to make a name for himself now that he’s taking over for Jaxson Dart, and he has a great chance to do so on a national broadcast early in the season as the SEC’s conference slate kicks off late Saturday afternoon. Expect the game to feature plenty of momentum swings early, with Kentucky trading quick scores to stay within striking distance while Ole Miss methodically moves the ball through balanced passing and running attacks. Simmons’ poise, combined with Kewan Lacy’s explosiveness, should allow the Rebels to sustain drives and capitalize in the red zone, particularly on high-leverage plays late in each half. Kentucky will generate sparks through Zach Calzada’s scrambles and intermediate passing, but sustaining long drives will be difficult against Ole Miss’ disciplined front and opportunistic secondary. By the final quarter, the Rebels’ depth, strategic adjustments, and dynamic playmakers should enable them to pull away, leaving Kentucky scrambling to keep pace in what is shaping up to be a high-intensity, early-season SEC showdown.

Final Score: #20 Ole Miss 31, Kentucky 13

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Kansas @ Missouri (-6.5) (O/U: 51.5)

Faurot Field at Memorial Stadium, Columbia, MO

3:30 pm, ESPN2

While I am excited to see new, fresh matchups that have big postseason implications for the first time like Michigan-Oklahoma and Illinois-Duke, it’s always refreshing to see an old, notorious rivalry become renewed for the first time in years. That’s what we’re getting out of the first Border War since 2011 between Kansas and Missouri, and with both teams looking to make statements of their own to begin the season, it’s a matchup that both fanbases have looked forward to seeing again for quite a while. Kansas comes in with momentum after two strong wins, led by dual-threat quarterback Jalon Daniels, who has shown an ability to extend plays and create big opportunities both through the air and on the ground. Running back Daniel Hishaw Jr. and wideout Emmanuel Henderson Jr. provide balance and explosiveness, while Cam Pickett adds a reliable receiving target to stretch the field. On defense, Trey Lathan and Lyrik Rawls have anchored a unit capable of making key stops and creating turnovers. Missouri, meanwhile, relies on Beau Pribula to run a versatile offense, supported by Ahmad Hardy’s dynamic rushing and Marquis Johnson’s ability to make contested catches. Defenders Josiah Trotter, Damon Wilson II, and Jalen Catalon offer playmaking ability and experience, helping the Tigers keep Kansas’ balanced attack in check. Expect a fast-paced, competitive game with big plays and momentum swings shaping this historic rivalry renewal.

Best Bet: Beau Pribula Anytime TD

Missouri’s quarterback battle seemed like one that they might not have been able to solve for this game, or even beyond, but after watching Beau Pribula play the way he did last week, even if it was Central Arkansas, the Tigers seemed to have found their guy. The Penn State transfer is a big-bodied quarterback who showed more of his arm strength than he did in Happy Valley, though many have long recognized his ability to run the football, and that dual-threat element will be central against Kansas. Pribula has already displayed the ability to extend plays, evade pressure, and make accurate throws on the move, giving Missouri a versatile weapon in both the passing and running game. He’ll have reliable targets in Johnson, Coleman, and Manning, and the Tigers will look to exploit matchups in the red zone, where Pribula’s size and mobility create clear advantages. While goal-line carries will occasionally go to Ahmad Hardy, Missouri has demonstrated a clear willingness to involve Pribula in scoring situations, increasing the likelihood he finds the end zone at least once. Against a Kansas defense that is improving but still integrating new linebackers and a retooled secondary, Pribula should find multiple opportunities for big plays, particularly on intermediate routes and scramble scenarios. If Missouri builds early momentum, he could quickly become the centerpiece of the offense, making him an enticing option for any scoring-focused prop bet in this highly-anticipated Border War matchup.

Prediction

This game is going to give both fanbases everything that they’ve been missing for years. Missouri has shown people that they’re still the same program that they have been for the last two seasons, and Kansas has found themselves in much better shape now than they were four years ago when Lance Leipold first got hired and Jalon Daniels took over the reigns at quarterback. Things will start out strong for the Tigers, as they jump out to an early lead behind their ground attack and then slowly work in their receivers late in the first half. Pribula uses his dual-threat ability to move the chains and keep Kansas defenders off balance, while Ahmad Hardy pounds the ball inside to set the tone and control the clock. Johnson and Manning provide reliable targets on intermediate routes, helping Missouri sustain long drives and add to their lead. Kansas begins to chip away after halftime, as Daniels extends plays with his legs and connects with Henderson and Pickett for chunk gains. Hishaw adds bursts of explosiveness in the run game, giving the Jayhawks hope for a late comeback. However, Missouri’s defense steps up when it matters most, with Trotter and Wilson making critical stops and Jalen Catalon coming up with a massive interception that swings momentum back to the Tigers, allowing them to hold off Kansas in the final minutes and seal a hard-fought victory in their first Border War matchup since their move to the SEC.

Final Score: Missouri 30, Kansas 27

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USF @ #13 Florida (-17.5) (O/U: 56.5)

Ben Hill Griffin Stadium, Gainesville, FL

4:15 pm, SEC Network

As Week 2 unfolds, Saturday afternoon’s showdown between USF and Florida might not sound like the most enticing matchup being a Group of Five vs ranked SEC team facing off, but if you look at the two teams closely, especially USF, it’s one of the better under-the-radar matchups of the weekend. The Bulls are entering this contest riding the national spotlight after a dominant opening-week performance over Boise State, a victory that has pundits and fans alike wondering if last year’s Group of Five CFP finalist is poised to carry that momentum into 2025. With the Bulls’ offense firing on all cylinders, led by quarterback Byrum Brown and a dynamic rushing attack anchored by Cartevious Norton and Alvon Isaac, it’s not hard to envision a scenario in which USF challenges Florida deep in the Swamp, signaling what some might call a “passing of the torch” moment for the Group of Five early on in the season. The Bulls’ playmakers in the passing game, particularly Chas Nimrod and Keshaun Singleton, offer explosive potential that can test even a talented Gator secondary. Florida, for its part, boasts one of its more complete rosters in recent memory, featuring a young yet skilled foundation under sophomore quarterback DJ Lagway, running back Jadan Baugh, and a receiving corps led by Eugene Wilson III and J. Michael Sturdivant, although Vernell Brown III, TJ Abrams, are two more guys to keep an eye on as well here. While the Gators clearly project as a future SEC powerhouse, questions remain about whether this matchup could serve as a lookahead spot in a schedule many consider among the nation’s most grueling, making Saturday’s game a true measuring stick for both programs.

Best Bet: USF +17.5

While Florida enters as a double-digit favorite, I’m loving the spot that USF presents as they seem to be one of those squads that gives great teams tough battles, largely due to the offensive-minded ingenuity of head coach Alex Golesh. Byrum Brown’s ability to extend plays with his legs and deliver precise passes under pressure gives the Bulls a multi-dimensional attack capable of testing even physically talented defenses, and now that he’s fully healthy and running at peak form, he can dissect zones with timing and accuracy while also exploiting gaps in the line with his athleticism, keeping the Gators’ front seven on their heels. Florida, meanwhile, has one of the SEC’s toughest early-season schedules, and this contest comes immediately ahead of a trip to Death Valley to face LSU, a matchup that could tempt Billy Napier’s squad to conserve energy or experiment with personnel in preparation for that high-profile clash. Golesh’s tempo-oriented schemes, combining quick passes, RPOs, and strategic misdirection, are tailor-made to exploit any momentary lapses in concentration or alignment from the Gators. With USF’s confidence skyrocketing after a dominant win over Boise State and Florida potentially looking ahead to their marquee matchup next weekend, the Bulls have the tools, talent, and tactical advantage to keep this game competitive and make the +17.5 spread a compelling wager for bettors early in the season.

Prediction

Expect this matchup to begin as a highly competitive, fast-paced battle, with USF immediately asserting itself and testing Florida’s young defensive front. Brown’s dual-threat skill set allows the Bulls to create explosive plays both through the air and on the ground, while Nimrod and Singleton provide consistent targets to stretch the field. USF’s tempo and creativity under Alex Golesh keep Florida’s offense off balance, allowing the Bulls to match the Gators play-for-play through the first half. It’s not hard to envision a scenario where USF keeps the game tied at halftime, or even holds a slim lead, as Florida adjusts to the pace and physicality of the Bulls’ attack. However, as the second half unfolds, Florida’s superior talent and depth begin to assert itself. The Gators’ offensive line starts to dominate the trenches, Baugh and Lagway establish rhythm, and Florida’s defense forces Brown into more predictable passing situations, limiting the Bulls’ ability to sustain drives. Late-game mistakes and turnovers eventually tilt the balance in Florida’s favor, allowing them to escape with a hard-fought win ahead of their high-profile SEC showdown at LSU. For USF, though, this is a coming-out party for a team now with proof that they are battle-tested, a legitimate Group of Five contender, and a team to watch near the CFP picture this season with a trip to Miami looming just as large next weekend.

Final Score: #13 Florida 35, USF 20

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Vanderbilt @ Virginia Tech (-1.5) (O/U: 47.5)

Lane Stadium, Blacksburg, VA

7:30 pm, ACC Network

Lane Stadium is another venue set to be rocking like crazy over the weekend for the first time this season as Brent Pry’s Virginia Tech team and Hokie fans welcome Clark Lea’s Vanderbilt squad to Blacksburg with Enter Sandman. The Hokies enter this matchup motivated to rebound from a frustrating loss to South Carolina, and they’ll look to lean on quarterback Kyron Drones’ ability to extend plays with his legs while also searching for more consistency in the passing game. Transfers Donovan Greene and Cameron Seldon, alongside Ayden Greene, will be asked to provide separation, open the field, and less drops, giving Drones options to push the ball downfield while still keeping the offense balanced with the ground attack. Vanderbilt, however, brings a confident and experienced group led by quarterback Diego Pavia, whose dual-threat skill set has become the heart of the Commodores’ identity. His improvisation under pressure and leadership give Vanderbilt a chance to challenge Tech’s retooled secondary, especially with tight end Eli Stowers and wideout Junior Sherrill capable of making critical plays in traffic. For the Commodores to stay in control, running back Sedrick Alexander will need to establish early success against a Hokies front that prides itself on physicality. Ultimately, this game may come down to which offensive line can steady itself first against relentless pressure, as both defenses aim to dictate tempo by winning battles in the trenches.

Best Bet: Virginia Tech -1.5

Vanderbilt took the Hokies to overtime last year in Nashville and stole a win late to shock the country and begin their quest for their first six-win season and bowl appearance in years. However, a different picture will be painted this time around as the crowd at Virginia Tech will give this Vanderbilt offense plenty to handle, even if they play in SEC venues on a yearly basis. The memory of that overtime loss still lingers in Blacksburg, and with the Hokies now looking to steady themselves after a frustrating fourth-quarter letdown in their opener, the motivation for revenge could not be higher. Kyron Drones has another year of growth behind him, and while he may not always light up the stat sheet, his experience gives Virginia Tech the poise they need in tight, physical games like this. Brent Pry also knows how critical this spot is, not just for momentum in September but for his own job security, and there is no question he will be leaning on his defense and the energy of Lane Stadium to deliver. With new contributors beginning to emerge on that side of the ball, the Hokies should be in good position to limit Vanderbilt’s ability to string together long drives. Given the revenge angle, home-field advantage, and urgency within the program, I love the -1.5 number for Virginia Tech.

Prediction

Vanderbilt is going to be just fine this year and should once again put themselves in contention for a second straight bowl appearance, which is no small feat for a program that struggled for so long to find consistency. Diego Pavia’s presence, along with a core of veteran playmakers, ensures that the Commodores will have chances to win some of the bigger games on their schedule. However, this matchup sets up as a difficult spot, especially with Pavia openly admitting that South Carolina is circled on their calendar for next weekend. That creates a real possibility of Vanderbilt getting caught looking ahead, and in an environment as hostile as Lane Stadium, any slight distraction can be costly. Virginia Tech doesn’t have the firepower to turn this into a shootout, but they don’t need to. The Hokies will rely on their running game, the steady growth of Kyron Drones, and a defensive front capable of creating constant pressure to wear down Vanderbilt’s offensive line. Expect a lower-scoring contest where possessions are at a premium, both sides leaning on their ground games and defenses to control the flow. In the end, the crowd should be the difference, as the Hokies take advantage of Vanderbilt’s mistakes and close out a much-needed win to avoid losing to back-to-back SEC squads and to gain some confidence just a few weeks before they begin conference play.

Final Score: Virginia Tech 24, Vanderbilt 20

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#12 Arizona State (-6.5) @ Mississippi State (O/U: 59.5)

Davis Wade Stadium, Starkville, MS

7:30 pm, ESPN2

Arizona State’s climb into the national spotlight under Kenny Dillingham was one of the sport’s biggest storylines a year ago, and the Sun Devils open their push for another playoff berth with a tricky road test in Starkville. The atmosphere at Davis Wade Stadium is always unforgiving for visiting offenses, and Mississippi State’s defense, though still inconsistent, has been reshaped through the transfer portal with more size and speed up front. That could be enough to keep things competitive for stretches, especially after the Bulldogs showed last season in Tempe they weren’t intimidated by ASU’s firepower. However, Sam Leavitt leads an Arizona State offense loaded with experience, and he has the ability to balance tempo with both his arm and his legs in a way that can punish defenses leaning too heavily on the run. While Mississippi State should be able to sustain drives with Davon Booth and Fluff Bothwell providing a backfield spark, this game feels like it will hinge on whether Blake Shapen can avoid costly turnovers against a secondary that thrives on creating takeaways. Arizona State has proven it can handle tense environments, and their ability to find explosive plays at the right moments could ultimately be the difference.

Best Bet: Jordyn Tyson o98.5 Receiving Yards

Even without Cam Skattebo in the backfield, Arizona State still boasts one of the most dynamic weapons in the country, and Jordyn Tyson’s production should once again be at the center of their offensive plan. Tyson has been a security blanket for Leavitt, a receiver capable of stretching the field or piling up yardage through sheer volume of catches, and in a matchup where Mississippi State’s corners remain unproven, he is positioned to thrive. The Bulldogs’ defense will try to limit rushing lanes and make Arizona State methodical, but that likely means Leavitt will pepper Tyson with targets on third downs, quick outs, and deep sideline routes. The number for his receiving yardage sits at 98.5, which may seem lofty, but considering how often Leavitt looks his way and how difficult it is for defenses to take him away without committing extra bodies, it still feels like value. Tyson has cleared this mark plenty of times against stronger secondaries, and Mississippi State’s lack of proven depth in coverage suggests more of the same here. Expect Leavitt to lean on him from the opening drive, and by the time the game tilts toward Arizona State’s tempo in the second half, the over should already be in play.

Prediction

Mississippi State may be a little more organized and physical in Jeff Lebby’s second year, but this matchup comes at a time when Arizona State is built to impose its will in close, hostile settings. The Bulldogs’ crowd and the cowbells will be a factor early, and their improved balance on offense should keep the game competitive into the second quarter, yet it’s difficult to see them sustaining drives once the Sun Devils’ front seven begins collapsing the pocket. If Shapen is pressured into obvious passing downs, turnovers will follow, especially with Brent Ward’s defense thriving on limiting explosive runs and forcing mistakes. On the other side, Arizona State doesn’t need to dominate in the run game to control tempo because Leavitt’s poise and Tyson’s reliability give them constant answers in critical situations, and that formula is exactly what carried them through big moments last season and remains in place now. Mississippi State will flash enough to stay within striking distance for a while, but over four quarters the depth, speed, and confidence of the Sun Devils should create the separation they need. For Dillingham’s group, this is the kind of win that keeps the playoff path clear, while the Bulldogs leave knowing progress has been made even in defeat.

Final Score: #12 Arizona State 34, Mississippi State 23

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#15 Michigan @ #18 Oklahoma (-5.5) (O/U: 44.5)

Gaylord Family Oklahoma Memorial Stadium, Norman, OK

7:30 pm, ABC

Finally, we turn our attention to Saturday night’s primetime game between Michigan and Oklahoma, the only ranked matchup of the weekend, two blue blood programs who have only had one meeting against one another. The storyline here revolves around how each side is built to challenge the other in very different ways, and it starts with the Wolverines breaking in five-star freshman quarterback Bryce Underwood on the road in a hostile environment. Underwood showed flashes of brilliance in the opener, but the reality of facing a Brent Venables team is a different kind of test, more specifically a team that normally relies heavily on its defense, one that will push his decision-making, poise, and ability to withstand pressure for four full quarters. Michigan will lean on star Alabama transfer Justice Haynes and the dominant ground game to settle him in, but new faces across the offensive line will have to hold up against a front that thrives on disruption and aggressive gap control. On the other side, the Wolverines’ own defense, which has experienced significant turnover after losing a large chunk of talent to the NFL, will have to quickly adjust while still relying on disciplined alignment and physical play to limit explosive plays and make the Sooners earn everything through methodical drives. For the Sooners, the intrigue comes with John Mateer, who stepped into the spotlight last week and quickly looked the part of a steady leader capable of spreading the ball around and keeping the offense balanced. This matchup doesn’t set up to be a shootout, but rather a battle of composure, discipline, and execution. The team that stays clean in the trenches and avoids turnovers will be the one that ultimately comes away with a defining victory.

Best Bet: John Mateer o241.5 Passing Yards

Oklahoma’s decision to bring in John Mateer has already emerged as one of the most impactful moves of the offseason, and his first game with the Sooners offered a clear glimpse of why Brent Venables entrusted him to lead the offense. After quietly making a name for himself at Washington State following Cam Ward’s transfer to Miami, Mateer took a chance on himself by moving to Norman, and he possesses all of the tools necessary to become the kind of superstar quarterback the program hasn’t seen since the Heisman-era talents under Lincoln Riley. Mateer was heavily involved in the passing game, even though he was up against an FCS defense, completing 30-of-37 passes for 397 yards and three touchdowns, demonstrating both accuracy and decisiveness while spreading the ball effectively to a deeper receiving corps. Michigan’s defense, which is still reshaping itself after losing multiple leaders to the NFL, will test him with pressure up front, but Mateer’s quick rhythm throws and ability to take advantage of intermediate-to-chunk opportunities should allow him to thrive. Venables’ scheme emphasizes efficiency over flash, and Mateer’s comfort in controlling tempo, making reads, and executing under pressure aligns perfectly with that approach. Considering how often the Sooners will look to him through the air rather than rely solely on the run, the 241.5 passing yards prop feels like a solid play, and Mateer’s arm is poised to be the most reliable and impactful offensive weapon on the field in this primetime matchup.

Prediction

Saturday night presents a somewhat rare quarterback duel between two very different yet elite talents, with the top overall high school recruit Bryce Underwood taking on the top overall transfer prospect John Mateer. Underwood has all the tools to enjoy a highly successful career at Michigan and beyond, but asking him to navigate a Brent Venables defense in just his second collegiate game, on the road against a hostile crowd, is a monumental challenge. The Wolverines’ defense, though historically disciplined under Wink Martindale, has experienced significant turnover following multiple departures to the NFL, and there are still questions about how quickly their new group can gel and handle a dynamic quarterback like Mateer. Michigan will lean on Haynes and Jordan Marshall to provide balance and sustain drives, but Oklahoma’s front and athletic linebackers are adept at disrupting timing, forcing third-and-long scenarios, and creating opportunities for turnovers. On the other side, Mateer’s calmness and command allow the Sooners to be patient, moving the ball methodically while still taking calculated shots downfield when openings present themselves. Oklahoma’s offense looked much more balanced last week, with contributions from a deep rushing attack and multiple receivers, but this game will be a lower-scoring, methodical battle similar to other high-profile matchups in recent weeks as Michigan’s defense will make them earn every yard. Ultimately, the Sooners’ new-look offense, defensive coaching and discipline, and overall roster balance should allow them to tilt the game in their favor and get their season started the right way with a huge win.

Final Score: #18 Oklahoma 24, #15 Michigan 16

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Make sure to stay tuned this weekend as we learn about more of college football’s top teams and as most teams inch their way closer to conference play!