The opening week of the 2025 NFL season has all the makings of a spectacle, setting the tone for what could be one of the most unpredictable years in recent memory. Old rivalries will immediately take center stage as divisional foes square off with the weight of early bragging rights on the line, while last season’s playoff powers return to the field intent on proving they still belong among the league’s elite. At the same time, several up-and-coming squads are looking to announce themselves as legitimate challengers, eager to turn offseason buzz into meaningful wins. Between star quarterbacks facing renewed expectations, revamped rosters unveiling fresh identities, and defenses eager to make statements against some of the NFL’s most dynamic playmakers, every game on the slate carries its own layer of intrigue. Fans won’t just be watching for results but for signs of who has the poise, discipline, and playmaking edge to seize momentum right from the start. Week 1 doesn’t decide anything in a long season, but it often reveals plenty, and this year’s matchups promise to spark storylines that will echo throughout the months ahead. Let’s take a look as I preview every game this weekend as the NFL kicks off their 2025 season, including favorite props to keep an eye on and final score predictions:

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Thursday, September 4

Cowboys @ Eagles (-8.5) (O/U: 48.5)

Lincoln Financial Field, Philadelphia, PA

8:20 pm, NBC/Peacock

Week 1 kicks off with a high-profile Thursday night showdown in Philadelphia as the Cowboys visit the defending Super Bowl champion Eagles. Dallas enters 2025 amid a transitional year under first-year head coach Brian Schottenheimer and new offensive coordinator Klayton Adams, both looking to implement their systems while navigating a roster in flux. Key pieces have shifted in the backfield and along the offensive line, and the absence of Micah Parsons leaves questions about how the Cowboys will generate pressure and contain dynamic quarterbacks like Jalen Hurts. Philadelphia, meanwhile, returns largely intact from their championship core, boasting an explosive offense led by Hurts and Saquon Barkley, a versatile and aggressive receiving corps, and a defensive front anchored by Jalen Carter and Jordan Davis. The Eagles’ combination of speed, experience, and depth makes them a formidable opening-week test, while Dallas will try to find stability early amid coaching transitions, key offseason acquisitions, and a young supporting cast eager to prove itself on a national stage. This opener sets the tone for both franchises, blending divisional pride with Super Bowl expectations.

Best Bet: Saquon Barkley o19.5 Rush Attempts

My favorite play for this matchup is Saquon Barkley to go over 19.5 rush attempts, and it’s one I feel confident hitting, especially considering how much Philly trusted him late in the regular season as well as the postseason last year. The Eagles are expected to take an early lead and maintain control for much of the game, and when they’re ahead, Philadelphia has a tendency to ride the run game to chew up the clock and keep the Cowboys’ offense off the field. Barkley is the centerpiece of that approach, thriving between the tackles behind a dominant offensive line anchored by Jordan Mailata and Lane Johnson, while also providing explosive plays when defenses overcommit to stopping the pass. Early-down work, third-down conversions, and red-zone touches all figure to funnel through him, and the Eagles’ game plan will likely emphasize sustained drives over quick shots, meaning Barkley should see a steady volume of carries throughout. Against a Dallas defensive front adjusting to life without Micah Parsons and DeMarcus Lawrence, the opportunity is there for Barkley to consistently churn out yards, and getting to 20 rush attempts looks extremely achievable in this matchup, especially considering the fact that he cleared that number in 13 out of 20 games last year, including the Eagles’ game against Cowboys in Week 16 when he tallied 31 carries.

Prediction

The Eagles enter Thursday night with championship momentum, continuity on both sides of the ball, and a roster built for sustained success, which will make life difficult for a Cowboys team still adjusting to new systems and personnel changes. Dallas will show flashes with Prescott and his talented receiving duo, and the run game should provide some balance, but containing Jalen Hurts’ dual-threat ability and a versatile backfield led by Saquon Barkley is a monumental task. Philadelphia’s defense, anchored by Carter, Davis, and a young, fast linebacker corps, should consistently force the Cowboys into uncomfortable passing situations while generating turnovers and applying pressure at key moments. Meanwhile, the Eagles’ offensive line, led by Jordan Mailata, will give Hurts time to pick apart a Dallas defense that is still finding its identity post-Parsons. Expect a hard-fought, physically demanding contest with Philadelphia gradually asserting itself, forcing Dallas to chase the game late, and the defending champs showing why they remain one of the league’s elite teams.

Final Score: Eagles 27, Cowboys 17

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Friday, September 5

Chiefs (-3.5) vs. Chargers (O/U: 46.5)

Corinthians Arena, São Paulo, Brazil

8 pm, YouTube

For the second straight year, the NFL returns to São Paulo to open its International Series slate, and this edition brings Patrick Mahomes and the Chiefs into a divisional clash with the Chargers, who serve as the designated home team under second-year head coach Jim Harbaugh. It’s a fascinating matchup that blends old connections with fresh arrivals, as both teams look to redefine themselves after eventful offseasons. Kansas City still bears the sting of its blowout defeat to Philadelphia in Super Bowl LIX, and Andy Reid’s group now faces the reality of a tougher AFC West than in years past, with the Chargers building a grittier identity under Harbaugh and the Broncos finding momentum under Sean Payton. For the leader trio of Mahomes, Travis Kelce, and Chris Jones, the challenge isn’t just rebounding from disappointment but staying ahead in a division that’s suddenly brimming with contenders again.

Best Bet: Keenan Allen o39.5 Receiving Yards

One of the biggest boosts for Justin Herbert this year is the return of Keenan Allen, who reunites with the franchise after spending 2024 in Chicago. Herbert has already shown trust in young targets like Ladd McConkey and will look to rookies KeAndre Lambert-Smith and Omarion Hampton to grow into roles, but Allen’s steady hands and precise routes make him the clear security blanket in Harbaugh’s system. Even though his stint with the Bears didn’t reach expectations, 39.5 yards feels like a low number for a six-time Pro Bowler who consistently produced in Los Angeles and has such established chemistry with Herbert. In a game where the Chargers will need to keep pace with Mahomes and find balance against a blitz-heavy defense, Greg Roman will look to involve Herbert’s arm a little more with a better receiving group and an inexperienced starter at running back, so Allen’s role in key passing downs should just lift him past that total.

Prediction

Despite both offenses looking healthier and deeper, the expectation here is for a tighter, lower-scoring contest compared to last year’s Brazil shootout between the Eagles and Packers, which leaned heavily on big rushing performances from Saquon Barkley and Jayden Reed. The Chargers’ offense has taken strides, and both Allen’s return and McConkey’s rise should keep the passing game afloat. However, this matchup feels like one that grinds more than it explodes as Mahomes may not put up gaudy numbers, yet Isiah Pacheco has the chance to reestablish himself with a strong outing on the ground. Defensively, Kansas City has the edge, as Steve Spagnuolo’s pressure schemes should cause more disruption than a Chargers front that’s still adjusting after losing Joey Bosa, Morgan Fox, and Asante Samuel Jr. A back-and-forth slugfest is on the horizon, but Kansas City’s depth and defensive experience tilt the balance their way. Just like many of their games last year, the Chiefs score a crucial touchdown late in the fourth, and they force a fumble and turnover within the final two minutes to stun the Chargers yet again.

Final Score: Chiefs 23, Chargers 19

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Sunday September 7

Buccaneers (-1.5) @ Falcons (O/U: 47.5)

Mercedes-Benz Stadium, Atlanta, GA

1 pm, FOX

The NFC South opener in Atlanta doesn’t just feel like another divisional clash; it feels like a measuring stick for two franchises at crossroads. Tampa Bay, the reigning division champion, is trying to thread the needle between keeping its veteran core competitive and developing the next wave of contributors. Baker Mayfield remains the heartbeat of the offense, and rookie Emeka Egbuka injects fresh energy into a receiving corps still headlined by longtime veteran Mike Evans. Yet, with Chris Godwin still recovering from his rough injury last year, Tristan Wirfs banged up, and a patchwork offensive line trying to gel, consistency is a lingering question. On the other side, Atlanta is no longer playing the long game of “maybe next year.” Raheem Morris has a roster that’s deeper, faster, and more balanced than the group that finished strong last season. Bijan Robinson’s blend of power and creativity fuels an offense built on rhythm and time of possession, while Michael Penix Jr. will still be a reliable option behind Kirk Cousins if he can’t provide more steady quarterback play that was missing in 2024. The defense, rebuilt around Leonard Floyd, AJ Terrell, and Jessie Bates III, brings both experience and aggression. It’s youth versus experience, cohesion versus transition, and a crowd that will make itself felt early and often. This is Atlanta’s chance to stake its claim as the new favorite in the South.

Best Bet: Falcons ML

There is something different about this Falcons team that I just can’t seem to put my finger on, but what feels downright wild is that they’re listed as underdogs in this matchup. A year ago, Atlanta took down Tampa Bay at home with a less complete roster and against a Buccaneers team that, on paper, looked stronger than the one rolling into Mercedes-Benz Stadium this weekend. Now, Raheem Morris has more weapons at his disposal, Bijan Robinson is primed for a sophomore leap, and Kirk Cousins gives the offense a steady hand. That ground-and-pound identity isn’t flashy, but it’s the kind of football that translates into wins, especially when paired with a defense built to force mistakes. Tampa still has playmakers for Baker Mayfield with both Evans and Egbuka to work with, but along with the absence of Godwin, this version of the Buccaneers feels fragile up front. Tristan Wirfs not being at full strength leaves questions about protection, and that’s a problem against a Falcons front that can collapse the pocket in big spots. Add in a home crowd eager to spark a season with expectations, and the formula tilts toward Atlanta. Straight-up, the Falcons’ balance and identity make their moneyline a sharper play than the oddsmakers suggest.

Prediction

What this game will ultimately come down to is which skill players will step up in the biggest way. Tampa Bay will land its punches, as Baker Mayfield isn’t shy about taking shots downfield, and Evans will almost certainly stretch the Falcons for an early big play. But what the Bucs can’t afford is to let Atlanta dictate pace, and that’s exactly where Bijan Robinson makes his mark. Expect Morris to call a deliberate game plan, leaning on methodical, clock-draining drives that force Tampa into a counterpunch role. That puts pressure on Mayfield to play from behind, something Atlanta’s pass rush is built to exploit. Even when Tampa manufactures a second-half rally, Atlanta’s balance keeps the Falcons steady: Cousins distributing in rhythm, the backfield chewing clock, and the defense making just enough plays to tilt field position. The turning point likely comes in the fourth quarter, when a long Falcons drive burns valuable time and leaves the Bucs scrambling with little margin for error. For Atlanta, a win here isn’t just about one game, but instead, it’s about proving they’ve graduated from “promising” to “contender.” For Tampa, it’s a long season ahead, but the lesson is a little more harsher unless their line solidifies quickly. This season will be a grind to keep pace in the South, and this game will reveal just that.

Final Score: Falcons 28, Buccaneers 24

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Giants @ Commanders (-6.5) (O/U: 45.5)

Northwest Stadium, Landover, MD

1 pm, FOX

The NFC East doesn’t waste time heating up, especially after a Thursday night kickoff game between Dallas and Philadelphia, and this opening-weekend meeting between the Giants and Commanders is a clash of two franchises staring at very different mirrors. New York lumbers into the season with Russell Wilson as its bridge quarterback, a retooled defense anchored by pass rushers Dexter Lawrence, Brian Burns, Kayvon Thibodeaux, and a superstar rookie in Abdul Carter, who Daboll hopes can spark life into a roster that’s long been more grit than flash. They’ll try to slow the game, pound the ball on the ground, and lean on Malik Nabers to ignite a passing game that too often stalls. Washington, meanwhile, is sprinting in the opposite direction with tempo, creativity, and depth on both sides of the ball. Jayden Daniels looks every bit like a franchise cornerstone, orchestrating Kliff Kingsbury’s fast-paced scheme with veteran toys like Terry McLaurin, Deebo Samuel, Austin Ekeler and Zach Ertz at his disposal. The Commanders thrive when their offense keeps the throttle down, and with a reloaded defense that now features Bobby Wagner, Von Miller, and Daron Payne up front as well as Marshon Lattimore in the secondary, this is a group built to capitalize on mistakes and turn them into momentum. The question is whether New York’s defensive front can create just enough chaos to keep things close, or if Daniels’ rhythm simply overwhelms them over four quarters.

Best Bet: Austin Ekeler o2.5 Receptions

The spread and the game total might be a little iffy, but there are some player props in this game that intrigue me. However, I’m going to stick with the reliability of Austin Ekeler’s hands, which is something that has helped him become a underrated household name over the past several years. He’s been one of the league’s most dependable pass-catching backs, and in Kingsbury’s scheme his role becomes even more essential. Washington doesn’t want Daniels forcing risky throws into tight coverage when the defense has already gifted him a check-down lifeline, and Ekeler is that lifeline. Expect quick flare routes, delayed releases into the flat, and swing passes designed to stretch linebackers horizontally, all of which build tempo and sustain drives. Even in games where the Commanders are dictating pace with chunk plays, Ekeler remains a quiet centerpiece in short-yardage and red-zone situations, where his quickness against slower defenders often tilts the balance. If the Giants decide to drop extra coverage against Washington’s receivers, Ekeler becomes even more involved as the easy outlet for Daniels to keep the chains moving. Three catches is a low bar for someone who consistently lands in the five-to-seven target range in games like this, and with Washington prioritizing efficiency early to avoid turnovers, I’d be absolutely dumbfounded if Ekeler doesn’t get at least three catches.

Prediction

This game feels like the kind of opener that paints a clear picture of where both teams stand in their respective arcs. The Giants, still very much in a transitional stage, will scrap their way into the mix early, piecing together methodical drives through a mix of Tyrone Tracy Jr.’s versatile runs and Russell Wilson’s controlled play-action looks. They’ll frustrate Washington’s defense at times with extended possessions that chew up clock, especially if Malik Nabers or Wan’Dale Robinson can find soft spots in coverage to keep the chains moving. But the Commanders’ speed and depth advantage eventually surfaces, particularly in the pass rush and secondary rotations, forcing New York to stay flawless to compete. Jayden Daniels finds his rhythm in the second quarter, leaning on Deebo Samuel’s versatility to stretch the defense horizontally and Austin Ekeler’s short-game reliability to sustain tempo. By halftime, Washington’s defense flips the momentum with a timely turnover, and the Giants never fully recover. Nabers flashes late with a few highlight grabs, but it’s not enough against a defense that thrives in obvious passing downs. In the fourth quarter, Daniels’ legs and a deep backfield rotation wear New York down with a long, clock-draining march. It’s not a runaway, but it’s a decisive, professional performance that underscores Washington’s playoff ambitions while reminding the Giants their rebuild still has more steps to climb.

Final Score: Commanders 27, Giants 16

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Bengals (-5.5) @ Browns (O/U: 47.5)

Huntington Bank Field, Cleveland, OH

1 pm, FOX

Few rivalries in football carry the simmering edge of the battle for Ohio between the Bengals and Browns, and opening the season in Cleveland only magnifies the stakes. Cincinnati enters with momentum and swagger, led by Joe Burrow and an offense that can shift gears from patient tempo to vertical strikes in a flash. Ja’Marr Chase and Tee Higgins stretch defenses in ways few teams can consistently counter, while a sturdier line has given Burrow more rhythm in his progressions. Across the field, Cleveland leans on a rugged formula: shorten the game with power runs, work play-action into intermediate windows, and count on Myles Garrett to disrupt drives with timely pressure. The Browns’ roster mixes promising youth with steady veterans but still feels unsettled, particularly at quarterback, where Joe Flacco currently holds the reins. Controlling tempo becomes vital under those circumstances, as keeping Burrow off the field is the Browns’ best hope. Division games often tilt on the margins, and this one could hinge on who wins third-and-medium, who establishes tone in the trenches, and who steals a possession with a timely takeaway. On paper, Cincinnati’s array of weapons provides the sharper edge, but these clashes rarely follow the script, especially given the charged Cleveland atmosphere and the Bengals’ history of slow September starts, making this AFC North opener a gritty, unpredictable tone-setter.

Best Bet: Chase Brown o19.5 Receiving Yards

Cincinnati’s offensive coordinator has compared Chase Brown to Austin Ekeler, painting him as a versatile weapon capable of exploiting defenses in ways that extend far beyond the ordinary running back role. In a scheme designed to get the most out of Burrow’s arm, every player on the field has a chance to touch the ball, but Brown’s unique skill set makes him especially dangerous in this matchup, especially against a defense that is weakest at linebacker. He is no longer a mere check-down outlet; he glides out of the backfield, drifts into soft zones on play-action, and finds subtle openings in the defense while maintaining the balance and vision to turn simple receptions into significant gains. The Browns will likely try to funnel attention toward Chase and Higgins, and that defensive focus only opens more opportunities for Brown to operate quietly but effectively. Each short swing pass or quick dump-off serves a dual purpose, giving Burrow time and space while allowing Brown to turn minimal yardage into momentum-changing chunks. His impact rarely comes from a single explosive play but from a consistent accumulation of touches that gradually tilts the field in Cincinnati’s favor. With the growing trust in his hands and a defense forced to respect every passing lane, projecting Brown to exceed 20 receiving yards feels more like an expected outcome of the Bengals’ nuanced, Burrow-led offense.

Prediction

This matchup carries all the intrigue of a classic AFC North clash, with extended possessions and flashes of sudden offensive brilliance that can swing momentum in an instant. Cincinnati comes into Cleveland with confidence, yet the memory of previous Week 1 struggles lingers, reminding the team and fans alike that early-season rust is always possible. The Bengals could stumble initially as timing issues and first-quarter misfires creep in, giving Cleveland a chance to assert itself with power running and carefully timed play-action that forces safeties to bite down and opens temporary lanes. Against a Browns roster still sorting out its identity, these early sequences may feel messy and test Cincinnati’s patience. Over time, however, Burrow’s poise and the offensive weapons at his disposal are likely to shift the tide quickly. The field-stretching ability of Chase and Higgins allows Cincinnati to turn even modest gains into game-altering plays, while adjustments along the offensive line and subtle protection tweaks help Burrow settle into a rhythm. The turning point will likely come when the defense forces a hurried throw or tips a pass, setting up a short field that the Bengals can convert into decisive points. Even if Cleveland attempts a late ground-based rally, Cincinnati’s talent, balance, and tempo make a repeat opening-week misstep against a markedly weaker opponent extremely unlikely.

Final Score: Bengals 30, Browns 23

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Panthers @ Jaguars (-3.5) (O/U: 46.5)

EverBank Stadium, Jacksonville, FL

1 pm, FOX

This matchup might not immediately scream “must-watch” to some people, but with the potential for offensive fireworks and the burden of carrying the subtle intrigue of early-season uncertainty for both teams, the narrative is as much about potential as it is about proven talent. The Jaguars bring a high-octane offense into Week 1, but the combination of a first-year head coach, a new offensive system, and an evolving supporting cast introduces enough questions to keep fans on edge, while the Panthers remain a work in progress under Dave Canales, gradually shaping an identity that leans on Bryce Young’s growth and the hope that their young skill players can make consistent impacts. Trevor Lawrence stands at the center of Jacksonville’s plans, surrounded by versatile receivers and running backs who can exploit space in both the short and intermediate game, yet the offensive line’s cohesion and the learning curve of a largely new coaching staff could introduce moments of miscommunication or timing issues. Carolina’s defense, while more developed than last year, is still finding its footing under Ejiro Evero, leaving openings for creative tempo-based schemes that can reward precise execution and take advantage of early-season misalignments. This contest will likely oscillate between methodical, clock-controlled drives and sudden bursts of offense, where turnovers, quick strikes, and individual plays could shift momentum multiple times, and the true intrigue lies in watching both teams test their chemistry, adaptability, and ability to respond to the unpredictable chaos that often defines Week 1.

Best Bet: Over 46.5

While these teams might not have the strongest-looking profiles on paper, there’s real intrigue here that lies in the duel between two of the NFL’s sharpest young offensive minds. Dave Canales and Liam Coen, two former Buccaneers offensive coordinators, both enter their first game of the season with systems designed to favor the quarterback, just like they both did with Baker Mayfield, and early indications suggest they could dominate this matchup. The Jags will rely on Lawrence’s ability to dissect defenses with a mix of quick rhythm passes and timely vertical shots to Thomas and potentially Hunter, turning methodical sequences into explosive scoring opportunities. Carolina, on the other side, relies on a system that favors strong quarterback play that aims to also maximize spacing and misdirection, allowing underneath routes and quick throws to transform into momentum-shifting gains. Both teams are still ironing out details and testing chemistry, and in a season opener, those growing pains often produce miscommunications and defensive lapses that can lead to easy points. Add in the possibility of turnovers or special-teams quirks, and there’s ample room for the scoreboard to swell. The combination of creative play-calling, youthful energy, and Week 1 unpredictability makes this game well-positioned to exceed the 46.5 total by a good bit, with both offenses capable of producing multiple touchdown drives and lots of points in many different ways.

Prediction

This matchup promises a brisk, back-and-forth contest where momentum swings as quickly as the offenses can exploit space and timing. Early on, the Panthers may strike first, with Young navigating a soft spot in the Jaguars’ secondary to deliver a precise touchdown that signals he is settling comfortably into Canales’ system, only for Lawrence to respond with a methodical, balanced drive that mixes creative runs and intermediate passing to reclaim the momentum and remind everyone of Jacksonville’s playmaking depth. The second quarter evolves into a microcosm of offensive ingenuity, with both defenses bending but refusing to collapse entirely, yielding a combination of field goals and explosive passes that leave the scoreboard almost perfectly balanced at halftime. Special teams may provide a pivotal third-quarter twist, whether through a dynamic return or a blocked kick, giving Jacksonville a short field and the chance to convert efficiently into points that tilt the contest. Carolina counters with a late, rhythm-driven drive that showcases offensive creativity and young talent, but the Jaguars’ ability to blend tempo, motion, and balanced play-calling ultimately generates just enough separation. By the final whistle, both squads walk away with more questions surrounding their respective defenses, but I have a little more faith that the Jags’ defense can make the extra stop or two to come out of this week with a much-needed win to set the tone for their season as they try and challenge the Texans in the AFC South.

Final Score: Jaguars 31, Panthers 27

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Steelers (-2.5) @ Jets (O/U: 38.5)

MetLife Stadium, East Rutherford, NJ

1 pm, CBS

Aaron Rodgers’ first game as a Pittsburgh Steeler carries the weight of both history and anticipation, blending the intrigue of a final NFL season with the drama of facing his former team and fellow ex-Steeler Justin Fields. On paper, it could appear as a measured, low-scoring contest, with Pittsburgh leaning on situational football, a conservative pace, and a defense designed to bend without breaking, while the Jets attempt to forge cohesion under first-year head coach Aaron Glenn and his revamped offensive and defensive schemes. Yet the presence of Rodgers immediately transforms Pittsburgh’s attack into a multifaceted threat, one that can shift from methodical, possession-based drives to sudden, explosive strikes that capitalize on DK Metcalf’s vertical prowess, Calvin Austin’s speed in space, and the versatility of tight ends like Pat Freiermuth and Jonnu Smith. Fields, for his part, will orchestrate a dynamic offense built to exploit mismatches with dual-threat creativity, relying on Breece Hall and Garrett Wilson to stretch the field while probing the edges of Pittsburgh’s aggressive front. The game’s narrative will be defined by the ebb and flow of third-down execution, play-action reads, and coaching adjustments, as the Steelers’ young line seeks to control the trenches and time of possession, and the Jets attempt to impose their new identity. While early uncertainty hangs over both sides, the command and experience that Rodgers possesses is a pretty legitimate reason why many believe the Steelers are the favorites to take this matchup and why they could still be a contender for another postseason appearance.

Best Bet: Calvin Austin III o23.5 Receiving Yards

Austin has emerged this offseason as one of the most intriguing figures in the Steelers’ revamped offensive lineup, and Rodgers’ confidence in him has been unmistakable throughout training camp. Observers have noted that Rodgers frequently turned to Austin during timing-route drills, quick-hitting sequences, and red-zone repetitions, emphasizing the young receiver’s ability to read coverage, gain separation, and turn short throws into meaningful chunks of yardage. That trust speaks volumes in an offense looking to strike a new balance, using Austin as a versatile option to stretch the field and maintain defensive respect across all levels. His speed, agility, and knack for finding open space in intermediate zones make him a natural complement to the running game, particularly in early-season situations when defenses are still sorting out communication and assignments. Against a Jets secondary still adjusting to first-year coaching schemes and new personnel, Austin’s quickness and route precision could turn a handful of touches into multiple chunks of yardage, giving him the opportunity to exceed 24 receiving yards without needing a single explosive play. Rodgers’ willingness to lean on him and the Steelers’ preference for high-percentage throws suggest that Austin will be an integral chain-mover in the offense, and his rapport with the veteran quarterback strengthens the case that he will see enough opportunities to hit the over here.

Prediction

This matchup is likely to unfold as a classic defensive struggle, with both units asserting control for long stretches and dictating the tempo, forcing each offense to earn every yard against disciplined, opportunistic fronts. The Steelers’ defensive front, anchored by TJ Watt and Cameron Heyward, combined with the new-look secondary Jalen Ramsey and Darius Slay joining Joey Porter Jr., will challenge Justin Fields at every turn, limiting his windows and forcing hurried decisions, while New York’s pass rush and linebacker rotation aim to disrupt Aaron Rodgers’ timing and test the chemistry of a retooled Pittsburgh line. Fields will be motivated to exact some payback after last season’s benching behind new Giants quarterback Russell Wilson, and Breece Hall’s dynamic rushing attack should offer short-term relief, yet the Jets’ young secondary and inconsistent communication could be exploited by Rodgers’ experience, football IQ, and desire to conclude his career on a high note. Special teams, third-down execution, and short-field opportunities are likely to create the pivotal moments in a contest defined less by explosive scoring and more by precision and situational mastery, and as the game wears on, Pittsburgh’s veteran leadership, clock control, and balanced attack should create just enough separation to hold off New York’s late rallies. Aaron Rodgers, as a result, opens his final season with a signature victory over his former team in front of the stadium that once felt like home, setting the tone for his farewell campaign.

Final Score: Steelers 20, Jets 17

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Dolphins @ Colts (-1.5) (O/U: 46.5)

Lucas Oil Stadium, Indianapolis, IN

1 pm, CBS

Week 1 will also usher in a very compelling matchup that feels more like a story of rebirth than a mere opener between the Dolphins and Colts, two franchises still searching for consistency and identity clash in a game that promises both intrigue and tension. Miami, brimming with talent yet still chasing cohesion, will feature plenty of speed with De’Von Achane, Tyreek Hill, and Jaylen Waddle, who can all really generate explosion and momentum for this offense here as well. However, they will need to hold onto hope that Tua Tagovailoa can stay healthy all season long, especially in this game as the Colts’ front will give his protectors plenty of trouble, and the early-season rust and adjustments to a continually evolving roster could complicate execution against a Colts front built to manipulate angles, disguise pressure, and also force quarterbacks into uncomfortable reads. Indianapolis, for its part, enters with cautious optimism, balancing new quarterback Daniel Jones, who’s looking for a redemption year of his own, with the power and patience of star back Jonathan Taylor, in a structure designed to control tempo and grind out possession. This contest will be less about flashy highlights than about field-position mastery, third-down conversions, and defensive subtlety, where each explosive play must be earned and mistakes are magnified, creating a tension-filled chess match. For fans, it represents a fascinating first glimpse at which of these two underperforming squads can rediscover rhythm, establish confidence, and begin a campaign that demands both creativity and discipline to turn potential into results.

Best Bet: Colts -1.5

I love this line for the Colts at -1.5 as it feels compelling for several intertwined reasons, starting with the undeniable advantage of playing at home, where Lucas Oil Stadium not only fuels Indianapolis’ confidence but also forces Miami into an environment that magnifies mistakes and disrupts rhythm. The Colts’ defense, anchored by a disruptive front and versatile secondary, enters with the tools and scheming capability to pressure quarterbacks, disguise coverages, and exploit mismatches, a task made easier by a Dolphins back end that is still finding its footing without Jalen Ramsey and with Kader Kohou returning from injury, leaving exploitable gaps in coverage and communication. On the offensive side, Jonathan Taylor’s presence transforms Daniel Jones’ options, as a rejuvenated running attack not only provides a high-floor method of sustaining drives but also opens up play-action opportunities, granting the passing game space to operate and keeping Miami’s defenders off balance. As the game progresses, Miami’s early burst and quick-strike tendencies will push the Colts to settle into a rhythm, with Jones gradually asserting control and Taylor churning out plenty of yards to balance their second-half offensive attack, ultimately allowing Indianapolis to orchestrate a methodical, momentum-shifting comeback that excites the home crowd and validates the Colts’ disciplined, strategic approach.

Prediction

The game will likely to erupt into a fast-paced opening, with Miami leaning into its speed and motion-heavy offense to strike early and establish a margin of security, pushing the Colts to respond in kind as they adjust to the Dolphins’ tempo. Tua Tagovailoa and his receivers, including De’Von Achane and Jaylen Waddle, will move the ball with quick-hitting passes and bursts through the ground game, testing Indianapolis’ discipline and communication, but the Colts will gradually find their footing as Daniel Jones settles into his role, reading the field with patience and delivering precision throws to Josh Downs and rookie Tyler Warren that shift momentum. Midway through the second half, a sustained, methodical drive led by Jones and powered by Jonathan Taylor’s consistent gains will flip the narrative, allowing Indianapolis to reclaim control and keep the clock in their favor, setting up the conditions for a dramatic comeback that thrills the home crowd. Each possession will feel like a statement, blending calculated aggression with disciplined execution, and by the final whistle, the Colts’ ability to balance tempo, protect the football, and exploit defensive lapses will leave fans buzzing across Lucas Oil Stadium, while honoring the legacy of Jim Irsay with a signature, late-game triumph.

Final Score: Colts 27, Dolphins 24

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Raiders @ Patriots (-2.5) (O/U: 44.5)

Gillette Stadium, Foxborough, MA

1 pm, CBS

This Week 1 showdown in Foxborough offers a fascinating lens into two AFC franchises eager to redefine themselves under recently hired championship-caliber coaches, each bringing experience, pedigree, and a vision for building sustainable success. Las Vegas enters the contest under Pete Carroll, now in his second season, blending his playoff-tested mindset with Chip Kelly’s high-tempo offensive creativity, while relying on Geno Smith to orchestrate rhythm, spacing, and timely decisions that will test both defensive discipline and resilience. Pass-catching threats like Brock Bowers promise plenty of explosiveness in the passing game along with possession threats like Tre Tucker and rookie Dont’e Thornton Jr., while Ashton Jeanty and Raheem Mostert provide balance and flexibility in the ground game, giving Carroll’s attack multiple dimensions. New England counters with Mike Vrabel at the helm, a coach whose championship experience is paired with a staff focused on developing young talent, integrating emerging playmakers, and sustaining a disciplined, versatile system. Drake Maye’s growth under center, complemented by rookie TreVeyon Henderson and the addition of Stefon Diggs, offers the Patriots a dynamic and balanced offensive arsenal, while their defense, anchored by former Lion Carlton Davis III and cornerback Marcus Jones, aims to limit mistakes and seize momentum in key moments, even with Christian Gonzalez sidelined. With both rosters featuring young cores, new faces, and untapped upside, this matchup is not only a test of schemes and execution but also a showcase of potential, making it a chess-like, high-stakes battle that could set the tone for an AFC season filled with intrigue, adjustment, and flashes of emerging excellence.

Best Bet: Stefon Diggs o46.5 Receiving Yards

Stefon Diggs enters the season as the undisputed top receiving option for Maye, and despite his age and the lingering effects of last year’s injury, he will get more than enough production to go over any of his projections. During his stint in Houston, Diggs eclipsed this total in five of eight games before suffering the setback at the end of October, and even before that, he consistently cleared similar benchmarks during his years in Buffalo, proving his reliability as a high-volume target in multiple offensive systems. While injuries and the natural wear that comes with being a veteran receiver could temper his explosiveness slightly, his route precision, field awareness, and ability to create separation remain elite traits, allowing him to turn even modest targets into meaningful yardage. The development for a quarterback like Maye, who is both accurate and poised under pressure, only enhances Diggs’ chances of surpassing expectations, as the offense is now built to leverage his ability to attack the middle of the field and exploit soft coverage zones. Even if New England’s defensive scheming attempts to funnel him into safer, shorter throws, Diggs has proven time and again that he can turn incremental gains into chain-moving drives, making it entirely plausible that he not only reaches 47 yards, but also reasserts himself as one of the AFC’s most dangerous wideouts capable of influencing games at every opportunity.

Prediction

The early stages of this matchup promise to be fast and electric for the Patriots as they come out of the gates firing on all cylinders, leveraging their balanced offensive attack and the chemistry between Maye and Diggs to carve through the Raiders’ defensive lines. New England’s offensive line looks poised to hold its own against Las Vegas’ front, giving Maye time to make precise throws to his receiving corps while Henderson grinds out yardage on the ground in his first NFL game, sustaining drives and keeping the Raiders’ pass rush in check. Pete Carroll’s squad responds with a mix of energy and ingenuity, as Geno Smith connects with his dynamic receiving duo of Bowers and Thornton, and Jeanty tests the Patriots’ defensive discipline with well-timed runs, creating moments of hope for a comeback. Yet, as the game progresses, Vrabel’s coaching acumen and his team’s depth begin to assert themselves, limiting explosive plays and forcing the Raiders into uncomfortable situations on crucial downs. While Carroll nearly engineers enough momentum to threaten the outcome, the Patriots’ cohesion, situational awareness, and defensive reliability prove too much, allowing them to maintain control and secure a hard-fought victory. This opening-week triumph not only moves New England to 1-0 but also injects a level of excitement and optimism for fans that hasn’t been felt in Foxborough since the Brady era, hinting at the potential for a breakthrough season under Vrabel.

Final Score: Patriots 24, Raiders 19

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Cardinals (-6.5) @ Saints (O/U: 43.5)

Caesars Superdome, New Orleans, LA

1 pm, CBS

Sunday’s clash between the Cardinals and Saints represents a microcosm of two very different trajectories in the NFC. Arizona is emerging from foundational years under Jonathan Gannon, blending youthful talent with steady veteran presence, led by Kyler Murray and rising second-year star Marvin Harrison Jr., who has the potential to recapture the dynamic playmaking of Larry Fitzgerald’s era. James Conner provides balance on the ground, allowing the offense to open up the playbook and keep defenses guessing, while a defensive unit anchored by Budda Baker and Zaven Collins seeks to pressure opponents consistently and force mistakes. The Saints, meanwhile, are navigating a full-scale rebuild under first-year head coach Kellen Moore, with an inexperienced quarterback room set to start Spencer Rattler that will be tested early against a disciplined, aggressive defense. On offense, Moore’s system leverages motion, spacing, and creativity to develop a young skill group, including Chris Olave and returning veteran Brandin Cooks, yet cohesion and timing remain in progress. This game shapes up as a vivid contrast between a roster on the rise and one deliberately in development, with Arizona likely to exploit defensive gaps, New Orleans hoping for growth and flashes of promise, and both teams’ young cores gaining valuable experience under contrasting pressures in a challenging NFC environment.

Best Bet: Cardinals -6.5

Arizona has the roster, balance, and momentum to handle a spread like this, especially against a Saints team still finding its footing under Moore. Murray will rely a good bit on James Conner to provide a physical, dependable presence in the backfield by keeping the ground game balanced, sustaining drives, controlling the clock, and opening up opportunities for play-action that could stretch the field both vertically and horizontally. Harrison Jr. has developed an intuitive connection with Murray, which should allow him to exploit matchups and consistently gain chunk yardage, making this spread feel well within reach. On the other side of the ball, New Orleans’ offensive line remains a point of concern, and with the quarterback situation unsettled, the Cardinals’ pass rush is positioned to create disruption, force hurried decisions, and generate negative plays that could tilt momentum early. While the Saints possess talented skill players and flashes of potential, their young defensive unit has shown susceptibility to big plays and breakdowns in coverage, leaving them vulnerable to a balanced and opportunistic opponent. When Arizona can dictate tempo, manage the clock, and press advantages in the passing and running game simultaneously, covering -6.5 becomes the most likely outcome in what promises to be a telling early-season test of both teams’ direction.

Prediction

Like I mentioned before, this game is likely to unfold in a way that emphasizes Arizona’s offensive balance and strategic execution, as Murray’s ability to read the field and distribute the ball to multiple playmakers allows the Cardinals to establish rhythm early, keeping the Saints’ defense off balance and forcing them into reactive assignments. Harrison Jr. will likely make a series of highlight-reel receptions that energize the Cardinals and set the tone in the Superdome, while Conner’s consistent, physical running creates sustained drives that chew the clock and open up opportunities for occasional deep shots downfield. New Orleans’ defense may respond with flashes of resistance, but the youth and inexperience along the front seven and in the secondary make it difficult for them to maintain consistent pressure, and the offensive line’s ability, or lack thereof, to protect Rattler or whichever quarterback ultimately starts will dictate whether the Saints can avoid quick turnovers and negative plays. Arizona positions themselves to assert control of the entire second half, forcing the home crowd into frustration as sustained drives limit scoring opportunities for the hosts. While the Saints may show brief sparks, the broader narrative favors a disciplined, balanced Cardinals offense that signals they are no longer simply rebuilding but beginning to stake a claim as a competitive force in the NFC West.

Final Score: Cardinals 26, Saints 13

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49ers (-2.5) @ Seahawks (O/U: 43.5)

Lumen Field, Seattle, WA

4:05 pm, FOX

Week 1 in Seattle presents an NFC West showdown that carries both intensity and narrative weight, as the 49ers aim to bounce back after a crushing disappointment last season and the Seahawks attempt to showcase an offense nearly unrecognizable from its previous iteration. San Francisco returns with Brock Purdy under center, healthy and motivated to lead an offense recalibrated under first-year coordinator Klay Kubiak, whose schemes are better designed to maximize the talent around him, particularly Christian McCaffrey in the backfield and George Kittle in the red zone. On the other sideline, the Seahawks field a reworked offense, led by Klay Kubiak’s brother, Klint, that has seen much of its previous star power depart, now built around Sam Darnold’s steady leadership, Kenneth Walker III’s dynamic running, and the additions of former Rams superstar Cooper Kupp stretching the field alongside Jake Bobo and rookie Tory Horton. While Seattle’s roster carries intrigue and depth, questions about cohesion and consistency loom large, especially with a largely unfamiliar offensive line. Defensively, the 49ers’ front seven with Nick Bosa, Fred Warner, and first-round rookie Mykel Williams seeks to disrupt timing, while the Seahawks’ secondary, headlined by Devon Witherspoon, must adjust quickly under pressure from San Francisco’s diversified passing attack. This matchup is likely to hinge on early execution, tempo control, and which team can impose its identity before the rivalry’s natural intensity escalates in the second half.

Best Bet: George Kittle Anytime TD

In a game where San Francisco’s offense will lean on George Kittle even more than before, he will also remain the most reliable red-zone weapon, a player whose skill set allows him to exploit soft coverage areas and create mismatches against linebackers and defensive backs alike. Even with an offseason of coaching changes and new faces around him, Kittle’s chemistry with Brock Purdy and understanding of Kubiak’s system ensures he will remain a focal point, particularly on short-yardage and play-action concepts designed to manipulate Seattle’s inexperienced coverage. The Seahawks’ linebackers and safeties, still adjusting to each other and to their new defensive coordinator nuanced rotations, could leave the middle of the field vulnerable, providing Kittle ample opportunities to sneak behind zones or slip past defenders in tight spaces. With McCaffrey demanding attention out of the backfield and wideouts like Jauan Jennings and Ricky Pearsall occupying secondary coverage, the strategic setup frequently leaves Kittle in single coverage or a soft window, making a touchdown attempt highly plausible. Against a Seahawks unit seeking identity and timing, a reliable, experienced target like Kittle is likely to find paydirt, making an anytime touchdown a strong wager that aligns with both San Francisco’s offensive philosophy and the matchup’s natural tendencies.

Prediction

Even though the 49ers enter this clash with one of the most talented rosters in the NFC West, the environment at Lumen Field and the unpredictability of a rivalry game set the stage for a tightly contested battle that could swing on a few critical plays. San Francisco’s offense, led by Brock Purdy and bolstered by Christian McCaffrey’s versatility and George Kittle’s red-zone reliability, will seek to establish rhythm early, but Seattle’s defensive front and energized home crowd are likely to disrupt timing and force the 49ers into uncomfortable down-and-distance situations, particularly on early drives. On the other side of the ball, Sam Darnold’s experience managing the Seahawks’ newly constructed offense will be tested, yet the combination of Kenneth Walker III’s explosiveness in the run game and the big-play potential of Cooper Kupp will allow Seattle to stretch the field and create high-leverage opportunities that could flip momentum in their favor. As the game unfolds, expect multiple lead changes with both teams trading blows, but Seattle’s ability to capitalize on a few key third-down stops and force San Francisco into a hurried, high-risk passing attack late in the fourth quarter could be the difference-maker. While the 49ers are disciplined and talented, the Seahawks’ home-field energy, opportunistic execution, and newfound offensive versatility may be just enough to secure a narrow, hard-fought victory in this season-opening NFC West showdown.

Final Score: Seahawks 24, 49ers 21

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Titans @ Broncos (-8.5) (O/U: 42.5)

Empower Field at Mile High, Denver, CO

4:05 pm, FOX

The Titans enter this road matchup searching for more clarity and stability than last year’s disaster of a season, yet their challenge could hardly be more daunting as they face one of the league’s deepest and most balanced rosters in the Broncos, all while contending with Denver’s notorious altitude advantage. Tennessee’s plan is straightforward on paper: lean on Tony Pollard and Tyjae Spears to establish rhythm and take pressure off of quarterback and top-overall NFL Draft pick Cam Ward, who faces one of the stiffest early tests of his professional career. However, the Broncos’ defensive front, bolstered by the edge presence of Nik Bonitto and the interior versatility of John Franklin-Myers, has the tools to collapse pockets and limit Tennessee’s rushing efficiency, which would leave Ward in long-yardage situations against an opportunistic secondary led by Patrick Surtain II. Denver, meanwhile, enters this season with real optimism around second-year quarterback Bo Nix, who has displayed poise and command in an offense now supported by JK Dobbins and rookie RJ Harvey in the backfield. The Broncos also possess the rare ability to dictate tempo and momentum, controlling the trenches offensively while disguising coverages and blitz packages defensively, making them a formidable matchup for a Titans squad that must be nearly flawless to keep the scoreline within reach in such a hostile setting.

Best Bet: Broncos -8.5

Though any 8.5-point line might typically be considered a risky wager in the NFL, Denver’s makeup and home environment suggest this line is one of the more favorable on the Week 1 slate. The Broncos’ roster depth, particularly in the trenches, gives them a considerable edge against a Titans team still working to find consistency on the offensive line. Denver’s ability to generate interior and edge pressure should keep Ward uncomfortable, as the pressure of Bonitto and Zach Allen create unrelenting pocket collapse. When forced into third-and-long situations, the Titans will struggle to create separation against the Broncos secondary, both of whom excel at closing throwing lanes. Offensively, the Broncos look poised for a breakout performance, with Nix distributing efficiently to playmakers like Sutton and Engram while relying on Dobbins to establish early ground control. Last season, Denver regularly handled teams that built their identity on power rushing, and the Titans’ formula is strikingly similar but lacks the line dominance necessary to impose their style in Denver. Combined with a high-tempo offense, creative play-action concepts, and the subtle factor of altitude wearing down opponents late, the Broncos’ ability to cover -8.5 feels not only realistic but a confident projection.

Prediction

This contest has the look of one where Denver asserts control early and steadily squeezes the life out of a Tennessee squad unable to generate sustained answers. Expect the Broncos to control possession through a disciplined ground game, leaning on both Dobbins and Harvey to wear down the Titans’ defensive front while giving Nix the flexibility to attack vertically in favorable down-and-distance scenarios. Tennessee’s best hope lies in explosive plays from Pollard or Ward improvising under duress, but Denver’s linebackers are disciplined enough to contain those moments, and their secondary’s ability to disguise coverages will likely produce stalled drives or turnovers. As the altitude takes hold in the second half, the Titans’ offensive line is projected to wear down, leading to increased pressure and hurried throws, which should further tilt momentum toward the Broncos. Denver’s offense, in contrast, has the personnel to remain fresh, rotating backs and spreading targets, ensuring consistent production even as the game becomes lopsided. By the fourth quarter, the Broncos’ superiority across every phase should be clear, with their defense suffocating Tennessee and their offense capitalizing on short fields and worn-down resistance. The result, while one-sided, serves as a declaration of Denver’s AFC ambitions and leaves Tennessee staring at early-season questions about its long-term direction.

Final Score: Broncos 34, Titans 7

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Lions @ Packers (-1.5) (O/U: 47.5)

Lambeau Field, Green Bay, WI

4:25 pm, CBS

The first of two high-profile NFC North clashes this weekend carries the familiar flavor of a long-standing rivalry, but the storylines feel fresher than they have in years, with both franchises approaching the meeting as a litmus test of where they stand in the conference hierarchy. Detroit comes to Lambeau Field not merely as a contender but as a team intent on proving that its rise has staying power, still fueled by the sting of last season’s postseason disappointment yet strengthened by a roster that blends continuity with carefully measured upgrades on both sides of the ball. Jared Goff remains the steadying force behind an offense that has evolved into one of the league’s most balanced units, driven by a backfield that punishes defenses with versatility and physicality, while his connection with a receiving corps that combines dependability with explosive speed makes Detroit a threat to stretch the field horizontally and vertically. The Packers, however, counter with an identity that has shifted dramatically, as Jordan Love is no longer the apprentice but the centerpiece of an offense buoyed by Josh Jacobs’ bruising presence in the run game and a youthful receiving group capable of winning deep. On defense, a rebuilt secondary and a front seven powered by new superstar addition Micah Parsons give Green Bay an edge in disruption, and with the atmosphere at Lambeau amplifying every snap, this matchup promises to unfold as one of the season’s most intricate and consequential chess matches.

Best Bet: Over 47.5

At first glance, a total of 47.5 might seem a bit aggressive for a divisional rivalry that so often turns into a physical battle, but the context of these two offenses and their recent history makes the over far more appealing than the under. Last season, the Lions and Packers split in terms of scoring output, with one matchup comfortably clearing that number thanks to explosive plays on both sides, while the other fell well short largely because of the heavy rainfall at Lambeau that slowed both passing games and tilted the script toward conservative, clock-draining runs. This time around, conditions are expected to favor offense, and the personnel on both teams suggests a more open-flowing game. Green Bay’s scheme is built on rhythm and balance, with Josh Jacobs demanding attention between the tackles while Love distributes to first-round rookie Matthew Golden, Romeo Doubs, and Jayden Reed, each capable of forcing mismatches against Detroit’s still-adjusting secondary. On the other side, Goff thrives in layered possessions, using Amon-Ra St. Brown and Sam LaPorta to control underneath windows while elite ground duo Jahmyr Gibbs and David Montgomery keep defenses from overcommitting to coverage. Both defenses have strengths up front but also show vulnerabilities in space, which invites opportunities for chunk plays, sudden scoring swings, and the type of counterpunching sequences that push totals higher. Combined with the history of shootouts when weather does not interfere, this matchup sets the stage for both offenses to move efficiently and surpass the point total line.

Prediction

In a matchup that carries the weight and intensity of a potential postseason preview, the expectation is for both offenses to trade blows in a way that highlights their depth, creativity, and adaptability. Green Bay should open the game with tempo, allowing Love to find an early rhythm by working quick passes to his much-improved wide receiver room, while Jacobs establishes his presence between the tackles, forcing Detroit’s linebackers to respect the run and widening windows for Love down the field. The Lions, however, are built to respond with their own brand of balance, leaning heavily on their Sonic and Knuckles duo to wear on the Packers’ front before Goff begins attacking through play-action, feeding St. Brown on intermediate routes and Jameson Williams on deep heaves to keep Green Bay’s safeties on their toes. This structure sets the stage for a game defined by momentum swings, where one long drive is answered almost immediately by a quick-strike series from the other side, amplifying the electricity inside Lambeau and pushing both coaching staffs to make bold, aggressive calls. In the end, the Packers’ home field advantage, combined with the defensive jolt provided by Parsons’ arrival, gives Green Bay just enough of an edge to seize a critical divisional win to start the year with a bang, one that reinforces the growing buzz around a franchise intent on reclaiming supremacy in the NFC North, as the Lions have a much more challenging season ahead.

Final Score: Packers 34, Lions 28

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Texans @ Rams (-3.5) (O/U: 43.5)

SoFi Stadium, Inglewood, CA

4:25 pm, CBS

The opening week stage could hardly be bigger, as two playoff-tested rosters collide in a matchup that feels more like January than September. Both the Texans and Rams made runs to the Divisional Round last season before falling just short against the eventual Super Bowl teams, and that shared disappointment has sharpened the stakes for this contest. The Texans have risen rapidly under DeMeco Ryans, whose discipline and vision have turned a roster brimming with elite young talent into one of the AFC’s most dangerous squads. CJ Stroud continues to grow into a franchise cornerstone, and with a backfield featuring Nick Chubb, who takes over Joe Mixon’s role for at least the next four weeks, alongside weapons like Nico Collins, Christian Kirk, and Dalton Schultz, Houston possesses both balance and explosiveness capable of controlling tempo. Defensively, the edge pairing of Will Anderson Jr. and Danielle Hunter, complemented by a secondary led by Derek Stingley Jr., Kamari Lassiter, and Jalen Pitre, allows Ryans to generate pressure while disguising coverage. The Rams, meanwhile, remain one of the NFL’s most consistently steady franchises under Sean McVay, whose offense blends veteran poise with young talent. Matthew Stafford provides championship-caliber leadership, and with Davante Adams joining Puka Nacua, Los Angeles boasts one of the league’s most dynamic receiving duos, while Kyren Williams and a young defensive front led by Jared Verse and Braden Fiske add both balance and bite. This game is less a typical Week 1 clash and more a proving ground, where both teams can demonstrate that last year’s Divisional Round exits were stepping stones, not ceilings.

Best Bet: Kyren Williams Anytime TD

If there is one constant in Sean McVay’s offensive philosophy, it is trusting his running backs to carry the load in critical situations, particularly near the red zone where disciplined execution often decides tight, high-stakes contests. Kyren Williams emerged last season as one of the league’s most dependable workhorse backs, scoring nine touchdowns despite splitting carries, and his role this season projects to be even more central behind a Rams offensive line that blends experience, depth, and athleticism. Houston’s defense, while talented and aggressive along the front seven, still exhibits occasional vulnerabilities near the goal line, and Williams’ combination of vision, burst, and patience makes him ideally suited to exploit them. Whether on a stretch run designed to take advantage of over-pursuit, a power up-the-middle in short-yardage situations, or a cleverly designed screen pass that allows him to slip into open space, Williams’ versatility ensures he is rarely a bystander and frequently a scoring threat. McVay’s balanced approach between the pass and the run allows Stafford to leverage his veteran receivers while keeping defenses honest, but early in the season, the coaching staff values simplicity and high-percentage opportunities, particularly inside the five-yard line. Given Williams’ consistency, proven goal-line acumen, and ability to absorb volume without faltering, his presence near the end zone feels less like a possibility and more like an inevitability, making him to score a touchdown a highly attractive and reliable option to pick here.

Prediction

From the first whistle, this clash will feel more like an early-season playoff preview, as both offenses possess the balance, creativity, and precision necessary to challenge even the most disciplined units. The Rams will likely establish a foundation on the ground, leaning on Williams to set tempo and command attention from Houston’s front seven, before Stafford begins systematically exploiting favorable matchups with Adams and Nacua, forcing the Texans to rotate coverages and anticipate the play-action that McVay and LaFleur have meticulously crafted. Houston, for their part, will respond with an offensive arsenal designed to keep Los Angeles on its heels, relying on Chubb in the backfield to shorten the game along with rotational options like Dameon Pierce, Dare Ogunbowale, and even rookie Woody Marks while Stroud attempts to stretch the field with Collins and second-round rookie Jayden Higgins, aiming to create chunk plays and sustain momentum. What elevates this matchup is the interplay of sustained, methodical drives and sudden, high-leverage momentum swings, each possession carrying the intensity and focus of a postseason contest despite the early calendar. While the Texans are poised for another extraordinary season, the Rams’ are going to slightly will themselves into the creation of just enough separation to claim a hard-fought statement victory, reminding Houston that elite talent still requires situational execution and resilience when facing a contender playing at full throttle.

Final Score: Rams 26, Texans 23

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Ravens (-1.5) @ Bills (O/U: 50.5)

Highmark Stadium, Orchard Park, NY

8:20 pm, NBC/Peacock

The first Sunday Night Football showdown between the Ravens and Bills carries a gravity that’s somewhat rarely seen this early in the year, more reminiscent of a mid-January playoff showdown than a typical opening-weekend contest, as both teams, having clashed a season ago in the AFC Divisional Round at the same venue, bring rosters forged through years of contention yet still chasing the elusive breakthrough past the Kansas City Chiefs. Baltimore arrives armed with a blend of power, precision, and adaptability, led by two-time MVP Lamar Jackson, whose dual-threat skill set is amplified by Derrick Henry’s punishing presence in the backfield, forming a ground-and-air tandem capable of controlling tempo, dictating defensive reactions, and systematically wearing down opponents over extended drives. John Harbaugh’s decades of experience, paired with Todd Monken’s increasingly nuanced offensive scheming, allows the Ravens to layer misdirection, power concepts, and play-action passes in ways that challenge Buffalo’s defensive assignments while exploiting even subtle lapses in coverage. Conversely, the Bills bring a combination of veteran leadership and ascending talent under Sean McDermott and Joe Brady, with reigning MVP Josh Allen orchestrating an offense designed to stretch the field both vertically and horizontally, enhanced by a fresh receiver group, a reliable James Cook at running back, and Dalton Kincaid serving as a key intermediate target. On defense, both squads feature aggressive front sevens, secondaries loaded with playmakers, and schemes designed to force turnovers and swing momentum. After years of narrowly falling short against Kansas City, these two franchises now combine elite talent, depth, and coaching mastery in ways that make them not just contenders but legitimate Super Bowl LX threats, poised to exploit the Chiefs’ growing vulnerability and finally convert sustained excellence into championship glory.

Best Bet: Derrick Henry o82.5 Rushing Yards

If there is one consistent theme in Baltimore’s offensive philosophy, it’s how much they rely on their run game and their commitment to controlling the line of scrimmage and finishing drives in situations where every yard carries heightened significance, a design perfectly suited to Derrick Henry’s rare combination of size, power, and speed. Last season, Henry came tantalizingly close to 2,000 rushing yards, and despite splitting touches, he consistently turned carries into explosive gains, including his previous matchup against Buffalo, where he totaled 199 yards and produced a single 87-yard run that alone would have exceeded the 82.5-yard threshold, highlighting his potential as both a workhorse and a big-play threat. While Buffalo’s defensive front is fast, aggressive, and capable of disrupting timing, especially up front, Henry’s vision, downhill acceleration, and ability to exploit over-pursuit mean that both traditional power runs and creative schemes, such as zone reads or screens, are likely to result in chunk plays. Monken’s scheme, although he loves working around his quarterback, still further maximizes Henry’s value by funneling goal-line, short-yardage, and early-down opportunities toward him, keeping defenses honest while sustaining drive rhythm. Combined with Baltimore’s healthy and balanced offensive line, which blends seasoned veterans with dynamic younger blockers capable of controlling the edge, Henry’s ability to get to 83 rushing yards feels more like a statistical inevitability, and early touches in high-leverage situations suggest he could reach this mark well before halftime if the Ravens execute as designed.

Prediction

Sunday night’s blockbuster in Buffalo has the feel of an early playoff game, the kind of matchup where every drive and coaching decision could shape the race for seeding and even determine who lands a first-round bye. The Bills come out firing, leaning on Allen’s arm and legs to seize control early, mixing Cook’s steady runs with Kincaid’s reliability across the middle and Khalil Shakir’s explosiveness on the outside. With Buffalo’s tempo dictating the rhythm, the Ravens find themselves on the defensive in the opening stretches, struggling to contain Allen’s improvisation and the Bills’ balanced approach. However, Baltimore refuses to fold, chipping away through Derrick Henry’s bruising downhill runs and Lamar Jackson’s ability to extend plays, eventually unlocking their passing game with DeAndre Hopkins and Zay Flowers testing the coverage deep and Mark Andrews anchoring the intermediate zones. The second half evolves into a tug-of-war, with disguised pressures, timely defensive adjustments, and sudden turnovers amplifying the stakes of every possession. Just when it appears Baltimore has clawed all the way back and momentum is leaning their way, Allen steadies the Bills on a final drive, guiding them into range for veteran Matt Prater, who drills the decisive kick, sealing a monumental, hard-fought Buffalo victory and sending a clear message that the Bills are ready to contend with anyone in the AFC.

Final Score: Bills 30, Ravens 27

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Monday, September 8

Vikings (-1.5) @ Bears (O/U: 43.5)

Soldier Field, Chicago, IL

8:15 pm, ABC/ESPN

Monday Night Football once again shines its spotlight on one of the NFL’s most historic rivalries, as the Vikings travel to Soldier Field for a prime-time clash with the Bears. What makes this chapter compelling is not the presence of grizzled veterans, but rather the gamble both franchises have placed on youth under center. J.J. McCarthy, finally healthy and stepping into his first full season as the Vikings’ starter, has been given the tools to succeed with one of the league’s most dangerous receivers in Justin Jefferson and a returning veteran in Adam Thielen, who reunited with his old team after two seasons in Carolina, a reliable veteran running back in Aaron Jones, and an experienced offensive line designed to keep him upright. Even with the pieces in place, however, McCarthy must still prove he can handle the week-to-week grind of the NFC North before Minnesota can be viewed as a true contender again. On the other sideline, Chicago has placed its future in the hands of Caleb Williams, the 2024 top overall draft pick whose improvisational flair has already electrified fans. While he benefits from DJ Moore’s consistency and DeAndre Swift’s versatility, much of the Bears’ young supporting cast, including Rome Odunze and rookies Luther Burden III and Colston Loveland, are still working to establish themselves at the professional level, especially after last year’s short-lived experiment with veteran Keenan Allen. That development could accelerate quickly under first-year head coach Ben Johnson, who arrives from Detroit with a reputation as one of football’s most inventive offensive minds. This matchup feels less like a routine divisional game and more like a litmus test for which team is further along in building its next competitive window.

Best Bet: Bears ML

I understand why the Bears enter this matchup as underdogs, yet I’m also a little surprised given how the circumstances actually tilt in their favor. For Minnesota, this game marks the beginning of the McCarthy era, but the first-year starter making his first on-field appearance after spending his entire rookie season on the IR faces a steep test trying to build off the momentum of last season, when Sam Darnold steadied the ship and pushed the Vikings into contention. McCarthy proved himself a winner at Michigan, but the NFL presents a different challenge, and in his first divisional start he will be heavily relied upon against a Chicago back seven that thrives on disguising coverages, forcing mistakes, and punishing quarterbacks who struggle to read quickly. His margin for error shrinks even further with Jordan Addison suspended and Jalen Nailor battling injuries, meaning that even with Jefferson, Thielen, and TJ Hockenson in the mix, the supporting cast isn’t at full strength. Soldier Field’s prime-time atmosphere only amplifies the challenge for a first-year starter fresh off injury. Meanwhile, the Bears look like a team overdue for a breakout, and Monday night provides the perfect stage to begin that rise under their new head coach, who knows how to exploit even the best defenses. Williams’ dual-threat playmaking, combined with a rebuilt veteran offensive line and a deepening arsenal of young weapons, makes Chicago an especially dangerous home underdog and a smart play to win outright.

Prediction

Like most rivalry matchups, I’m not expecting either side to give much of an inch early on, and the opening sequences are likely to be dictated by strong defensive play rather than offensive fireworks. Both front sevens are equipped to disrupt rhythm at the line of scrimmage, forcing Williams and McCarthy alike into uncomfortable situations and testing their patience with sustained drives. As the game wears on, however, it feels inevitable that the offenses will begin to settle, with Minnesota leaning on Jefferson’s explosiveness to flip momentum and Jones’ steady production to keep pressure off their rookie quarterback, while Chicago relies on Williams’ ability to extend plays as well as Moore’s knack for creating after the catch. The margin, then, becomes razor thin, hinging not on an overwhelming advantage but rather on which quarterback is capable of making a handful of defining plays in the moments that matter most. In that respect, the edge leans toward Williams, whose creativity and composure already inspire confidence in crunch-time settings, and some of their newer young talent at the skill spots will make names for themselves early on in their careers, whether that’s Odunze, Burden, Loveland, or all three players. When the game reaches its decisive sequence, it’s Chicago’s defense that steps up with a stop, securing Ben Johnson’s first career victory, acknowledging that they’ve found the right guy to lead their squad, and signaling the beginning of what could finally be the Bears’ long-awaited new era.

Final Score: Bears 23, Vikings 20

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Make sure to stay tuned this weekend as we learn a little more about some of the top teams in a stacked Week 1 slate to kick things off for the 2025-26 NFL season!